Deuter, Daniel and Hense, Katharina and Kunkel, Kevin and Vollmayr, Johanna and Schachinger, Sebastian and Wendl, Christina and Schicho, Andreas and Fellner, Claudia and Salzberger, Bernd and Hitzenbichler, Florian and Zeller, Judith and Vielsmeier, Veronika and Dodoo-Schittko, Frank and Schmidt, Nils Ole and Rosengarth, Katharina (2024) SARS-CoV2 evokes structural brain changes resulting in declined executive function. PLOS ONE, 19 (3): e0298837. ISSN 1932-6203,
Full text not available from this repository. (Request a copy)Abstract
Background Several research has underlined the multi-system character of COVID-19. Though effects on the Central Nervous System are mainly discussed as disease-specific affections due to the virus' neurotropism, no comprehensive disease model of COVID-19 exists on a neurofunctional base by now. We aimed to investigate neuroplastic grey- and white matter changes related to COVID-19 and to link these changes to neurocognitive testings leading towards a multi-dimensional disease model.Methods Groups of acutely ill COVID-19 patients (n = 16), recovered COVID-19 patients (n = 21) and healthy controls (n = 13) were prospectively included into this study. MR-imaging included T1-weighted sequences for analysis of grey matter using voxel-based morphometry and diffusion-weighted sequences to investigate white matter tracts using probabilistic tractography. Comprehensive neurocognitive testing for verbal and non-verbal domains was performed.Results Alterations strongly focused on grey matter of the frontal-basal ganglia-thalamus network and temporal areas, as well as fiber tracts connecting these areas. In acute COVID-19 patients, a decline of grey matter volume was found with an accompanying diminution of white matter tracts. A decline in executive function and especially verbal fluency was found in acute patients, partially persisting in recovered.Conclusion Changes in gray matter volume and white matter tracts included mainly areas involved in networks of executive control and language. Deeper understanding of these alterations is necessary especially with respect to long-term impairments, often referred to as 'Post-COVID'.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACANTHAMOEBA-KERATITIS; CONFOCAL MICROSCOPY; BACTERIAL KERATITIS; DIAGNOSIS; FUNGAL; PSEUDOMONAS; FEATURES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Neurochirurgie Medicine > Lehrstuhl für Röntgendiagnostik Medicine > Abteilung für Krankenhaushygiene und Infektiologie Medicine > Zentrum für Neuroradiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jul 2025 08:37 |
| Last Modified: | 15 Jul 2025 08:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/63394 |
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