Cardon, Iseline and Grobecker, Sonja and Kuecuekoktay, Selin and Bader, Stefanie and Jahner, Tatjana and Nothdurfter, Caroline and Koschitzki, Kevin and Berneburg, Mark and Weber, Bernhard H. F. and Stoehr, Heidi and Hoering, Marcus and Liebisch, Gerhard and Braun, Frank and Rothammer-Hampl, Tanja and Riemenschneider, Markus J. and Rupprecht, Rainer and Milenkovic, Vladimir M. and Wetzel, Christian H. (2024) Mitochondrial and Cellular Function in Fibroblasts, Induced Neurons, and Astrocytes Derived from Case Study Patients: Insights into Major Depression as a Mitochondria-Associated Disease. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25 (2): 963. ISSN 1661-6596, 1422-0067
Full text not available from this repository. (Request a copy)Abstract
The link between mitochondria and major depressive disorder (MDD) is increasingly evident, underscored both by mitochondria's involvement in many mechanisms identified in depression and the high prevalence of MDD in individuals with mitochondrial disorders. Mitochondrial functions and energy metabolism are increasingly considered to be involved in MDD's pathogenesis. This study focused on cellular and mitochondrial (dys)function in two atypical cases: an antidepressant non-responding MDD patient ("Non-R") and another with an unexplained mitochondrial disorder ("Mito"). Skin biopsies from these patients and controls were used to generate various cell types, including astrocytes and neurons, and cellular and mitochondrial functions were analyzed. Similarities were observed between the Mito patient and a broader MDD cohort, including decreased respiration and mitochondrial function. Conversely, the Non-R patient exhibited increased respiratory rates, mitochondrial calcium, and resting membrane potential. In conclusion, the Non-R patient's data offered a new perspective on MDD, suggesting a detrimental imbalance in mitochondrial and cellular processes, rather than simply reduced functions. Meanwhile, the Mito patient's data revealed the extensive effects of mitochondrial dysfunctions on cellular functions, potentially highlighting new MDD-associated impairments. Together, these case studies enhance our comprehension of MDD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTIDEPRESSANT DRUGS; STEM-CELLS; DISORDER; EFFICIENT; CALCIUM; NEURODEGENERATION; DYSFUNCTION; INTEGRATION; MECHANISMS; INDUCTION; major depressive disorder; mitochondrial functions; mitochondriopathy; treatment-resistant depression; iPS-neurons; iPS-astrocytes |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Lehrstuhl für Humangenetik Medicine > Lehrstuhl für Neurologie Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Jul 2025 06:47 |
| Last Modified: | 16 Jul 2025 06:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/63398 |
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