Terzi, Menderes Yusuf and Casalis, Pablo and Lang, Veronika and Zille, Marietta and Bruendl, Elisabeth and Stoerr, Eva-Maria and Brawanski, Alexander and Vajkoczy, Peter and Thomale, Ulrich and Pina, Ana Luisa (2015) Effects of pigment epithelium-derived factor on traumatic brain injury. RESTORATIVE NEUROLOGY AND NEUROSCIENCE, 33 (1). pp. 81-93. ISSN 0922-6028, 1878-3627
Full text not available from this repository. (Request a copy)Abstract
Purpose: Pigment epithelium-derived factor (PEDF) is a multifunctional protein with antiangiogenic, anti-inflammatory, neurotrophic and neurogenic properties. The effect of PEDF on traumatic brain injury (TBI) has not been explored. In this study, we aimed to show the in vivo effects of PEDF on lesion volume, cell death and cell proliferation after TBI. Methods: Rats were subjected to controlled cortical impact injury (CCII). PEDF mRNA brain levels were measured by RT-PCR. The lesion volume, cell proliferation, cell death and microglia activation were assessed in the brains of lesioned animals with intraventricular alzet infusion of PEDF or aCSF, and intraperitoneal injections of BrdU. Results: We detected a significant increase ofPEDFmRNAlevels after TBI. PEDFintraventricular infusion showed no significant effect on the contusion volume, whereas the number of dead cells, activated microglia, BrdU- positive cells around the lesion were significantly decreased. In contrast, PEDF application increased cell proliferation in the ipsilateral subventricular zone. No effect was found on cell proliferation in the dentate gyrus. Conclusion: The present work indicates that PEDF acts as a multifunctional agent after TBI influencing cell death, inflammation and cell proliferation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONTROLLED CORTICAL IMPACT; CEREBELLAR GRANULE CELLS; FACTOR PEDF; GROWTH-FACTOR; HEAD-INJURY; RAT; PROLIFERATION; MODEL; BDNF; EXPRESSION; PEDF; traumatic brain injury; cell death; microglia; SVZ |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurochirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Aug 2019 11:11 |
| Last Modified: | 02 Aug 2019 11:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/6341 |
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