Pflaum, Jasmin C. and Gaertner, Vincent D. and Brandstetter, Susanne and Apfelbacher, Christian and Melter, Michael and Koeninger, Angela and Kabesch, Michael (2024) Defining familial longevity and developing a familial longevity score for unbiased epigenetic studies in a birth cohort. EPIGENOMICS, 16 (17). pp. 1149-1158. ISSN 1750-1911, 1750-192X
Full text not available from this repository. (Request a copy)Abstract
Aim: Longevity accumulating in families has genetic and epigenetic components. To study early and unbiased epigenetic predictors of longevity prospectively, a birth cohort would be ideal. However, the original family longevity selection score (FLoSS) focuses on populations of elderly only. Methods: In the German birth cohort KUNO-Kids we assessed when information for such scores may be best collected and how to calculate an adapted FLoSS. Results: A total of 551 families contributed to adapted FLoSS, with a mean score of -0.15 (SD 2.33). Adapted FLoSS >= 7 as a marker of exceptional longevity occurred in 3.3% of families, comparable to original FLoSS in elderly. Conclusion: An adapted FLoSS from data collectable postnatally may be a feasible tool to study unbiased epigenetic predictors for longevity. TWEETABLE ABSTRACT In the German birth cohort KUNO-Kids we assessed if and how a family longevity selection score may best be calculated to study unbiased epigenetic predictors for longevity in the future.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENOME-WIDE ASSOCIATION; LINKAGE ANALYSIS; GENETICS; LIFE; birth cohort; familial longevity; FLoSS; KUNO-Kids study; longevity; newborn |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Geburtshilfe) Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jul 2025 09:23 |
| Last Modified: | 15 Jul 2025 09:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/63443 |
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