Weber, Florian and Utpatel, Kirsten and Evert, Katja and Weiss, Thomas S. and Buechler, Christa (2024) Hepatic Bone Morphogenetic Protein and Activin Membrane-Bound Inhibitor Levels Decline in Hepatitis C but Are Not Associated with Progression of Hepatocellular Carcinoma. BIOMEDICINES, 12 (10): 2397. ISSN , 2227-9059
Full text not available from this repository. (Request a copy)Abstract
Background/Objectives: Bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) is an antagonist of transforming growth factor (TGF)-beta type 1 signaling. BAMBI functions as an anti-fibrotic protein and exerts pro- as well as anti-cancerogenic activities. Our study aimed to correlate hepatocyte BAMBI protein levels in hepatocellular carcinoma (HCC) with T stage, lymph node invasion, vessel invasion, grading, tumor size and Union for International Cancer Control (UICC) stage, as well as with liver inflammation and fibrosis stages. Methods: Hepatocyte BAMBI protein expression was assessed by immunohistochemistry in HCC tissues of 320 patients and non-tumor tissues of 51 patients. Results: In the HCC tissues of the whole cohort and sex-specific analysis, BAMBI protein was not related to T stage, vessel invasion, lymph node invasion, histologic grade, UICC stage and tumor size. Accordingly, BAMBI was not associated with overall survival, recurrence-free and metastasis-free survival. BAMBI protein levels in tumor and non-tumor tissues were not related to inflammation and fibrosis grade. BAMBI protein levels in HCC tissues and non-tumor tissues from HCC patients, which were analyzed by immunoblot in a small cohort and by immunohistochemistry in the tissues of patients described above, were similar. Notably, BAMBI protein was low-abundant in HCC tissues of hepatitis C virus (HCV) compared to hepatitis B virus (HBV)-infected patients with comparable disease severity. Immunoblot analysis revealed reduced BAMBI protein in non-tumor tissues of patients with HCV in comparison to patients with HBV and normal human liver tissues. Conclusions: In summary, this analysis showed that hepatocyte BAMBI protein levels of patients with HCC are related to HCV infection rather than the severity of the underlying liver disease and cancer staging.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PSEUDORECEPTOR BMP; FATTY LIVER; BAMBI; EXPRESSION; DIAGNOSIS; DIFFERENTIATION; REPLICATION; METABOLISM; CIRRHOSIS; PATHWAY; histologic grade; fibrosis; hepatitis; UICC score; immunohistochemistry |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Kinder- und Jugendpsychiatrie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Jul 2025 06:36 |
| Last Modified: | 18 Jul 2025 06:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/63455 |
Actions (login required)
 |
View Item |
