Scurr, Lyndee L. and Haferkamp, Sebastian and Rizos, Helen (2017) The Role of Sumoylation in Senescence. In: UNSPECIFIED Advances in Experimental Medicine and Biology,, 963 . SPRINGER INTERNATIONAL PUBLISHING AG, CHAM, pp. 215-226. ISBN 978-3-319-50044-7; 978-3-319-50043-0
Full text not available from this repository. (Request a copy)Abstract
Cellular senescence is a program initiated by many stress signals including aberrant activation of oncogenes, DNA damage, oxidative lesions and telomere attrition. Once engaged senescence irreversibly limits cellular proliferation and potently prevents tumor formation in vivo. The precise mechanisms driving the onset of senescence are still not completely defined, although the pRb and p53 tumor suppressor pathways converge with the SUMO cascade to regulate cellular senescence. Sumoylation translocates p53 to PML nuclear bodies where it can co-operate with many sumoylated co-factors in a program that activates pRb and favors senescence. Once activated pRb integrates various proteins, many of them sumoylated, into a repressor complex that inhibits the transcription of proliferation-promoting genes and initiates chromatin condensation. Sumoylation is required for heterochromatin formation during senescence and may act as a scaffold to stabilize the pRb repressor complex. Thus, SUMO is a critical component of a tumor-suppressor network that limits aberrant cell proliferation and tumorigenesis.
| Item Type: | Book Section |
|---|---|
| Uncontrolled Keywords: | NUCLEAR-BODY FORMATION; CELL-CYCLE ARREST; IN-VIVO; SUMO MODIFICATION; BETA-GALACTOSIDASE; TELOMERE LENGTH; PREMATURE SENESCENCE; HETEROCHROMATIN FOCI; FISSION YEAST; P53 ACTIVITY; Heterochromatin formation; p53; PML nuclear bodies; pRb; Senescence Telomeres |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:01 |
| Last Modified: | 28 Apr 2020 08:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/635 |
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