Xu, Congde and Roth, Nastasia and Heidel, Carolin and Hubauer, Ute and Wallner, Stefan and Burkhardt, Ralph and Meindl, Christine and Holzamer, Andreas and Hilker, Michael and Creutzenberg, Marcus and Sossalla, Samuel and Maier, Lars Siegfried and Debl, Kurt and Jungbauer, Carsten (2024) Prognostic value of N-Acetylglucosaminidase and Kidney-injury-molecule-1 in TAVI patients with severe aortic stenosis. BIOMARKERS IN MEDICINE, 18 (24). pp. 1075-1085. ISSN 1752-0363, 1752-0371
Full text not available from this repository. (Request a copy)Abstract
Aim Cardiorenal syndrome (CRS) is common in severe aortic stenosis (AS). Previous studies revealed N-Acetylglucosaminidase (NAG) and Kidney-injury-molecule-1 (KIM-1) as potential markers for CRS. The study aimed to investigate the prognostic capability of NAG, KIM-1, NT-proBNP in severe AS before TAVI. Materials & Methods Plasma and urine samples were collected from 151 participants before TAVI. Long-term follow-up (median follow-up time 31 months) was conducted to assess all-cause mortality and a composite endpoint of mortality and congestive heart failure. Results NT-proBNP was significantly elevated in classical low-flow, low-gradient AS compared to other severe AS phenotypes (p < 0.01), unlike NAG and KIM-1 (each p = n.s.). During follow-up, 40 patients (26.5%) died, and 58 patients (38.4%) reached the composite endpoint. Elevated baseline levels of NAG and KIM-1 were associated with increased risk of all-cause mortality in Kaplan-Meier analysis, like NT-proBNP (each p<0.05). NAG and STS-Score were revealed as significant predictors for all-cause mortality in multivariable COX-regression analysis (each p<0.05), unlike NT-proBNP, KIM-1, eGFR, and clinical parameters (each p=n.s.). Conclusion Baseline NAG and, to a lesser degree, KIM-1 and NT-proBNP provide significant predictive value for all-cause mortality in patients with severe AS before TAVI.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | KIDNEY INJURY MOLECULE-1; BETA-D-GLUCOSAMINIDASE; VALVE-REPLACEMENT; NATRIURETIC PEPTIDE; EJECTION FRACTION; TUBULAR DAMAGE; HEART-FAILURE; LOW-FLOW; TRANSCATHETER; IMPACT; Tubular biomarkers; NAG; KIM-1; long-term prognosis; TAVI; cardiorenal syndrome; NT-proBNP |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jul 2025 12:06 |
| Last Modified: | 15 Jul 2025 12:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/63516 |
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