Rappeneau, Virginie and Diaz, Fernando Castillo (2024) Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 161: 105675. ISSN 0149-7634, 1873-7528
Full text not available from this repository. (Request a copy)Abstract
Social behaviour is essential for animal survival, and the hypothalamic neuropeptide oxytocin (OXT) critically impacts bonding, parenting, and decision-making. Dopamine (DA), is released by ventral tegmental area (VTA) dopaminergic neurons, regulating social cues in the mesolimbic system. Despite extensive exploration of OXT and DA roles in social behaviour independently, limited studies investigate their interplay. This narrative review integrates insights from human and animal studies, particularly rodents, emphasising recent research on pharmacological manipulations of OXT or DA systems in social behaviour. Additionally, we review studies correlating social behaviour with blood/cerebral OXT and DA levels. Behavioural facets include sociability, cooperation, pair bonding and parental care. In addition, we provide insights into OXT-DA interplay in animal models of social stress, autism, and schizophrenia. Emphasis is placed on the complex relationship between the OXT and DA systems and their collective influence on social behaviour across physiological and pathological conditions. Understanding OXT and DA imbalance is fundamental for unravelling the neurobiological underpinnings of social interaction and reward processing deficits observed in psychiatric conditions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VENTRAL TEGMENTAL AREA; NUCLEUS-ACCUMBENS OXYTOCIN; LONG-TERM-MEMORY; PARAVENTRICULAR NUCLEUS; MATERNAL-BEHAVIOR; PENILE ERECTION; DEFEAT STRESS; REWARD; RELEASE; BRAIN; Oxytocin; Dopamine; Social behaviour |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Jul 2025 07:05 |
| Last Modified: | 17 Jul 2025 07:05 |
| URI: | https://pred.uni-regensburg.de/id/eprint/63537 |
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