Prasser, Julia and Schecklmann, Martin and Poeppl, Timm B. and Frank, Elmar and Kreuzer, Peter M. and Hajak, Goeran and Rupprecht, Rainer and Landgrebe, Michael and Langguth, Berthold (2015) Bilateral prefrontal rTMS and theta burst TMS as an add-on treatment for depression: A randomized placebo controlled trial. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 16 (1). pp. 57-65. ISSN 1562-2975, 1814-1412
Full text not available from this repository. (Request a copy)Abstract
Objectives. Repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral-prefrontal cortex (DLPFC) exerts antidepressant effects. In this randomised controlled clinical trial we aimed to test the safety and therapeutic efficacy of bilateral theta-burst stimulation (TBS) as an add-on therapy to standard treatment of major depression. Methods. Fifty-six patients diagnosed with a moderate to severe depressive episode received 15 daily treatments of either rTMS (110% motor-threshold; rightDLPFC, 1000 stimuli at 1 Hz + leftDLPFC, 1000 stimuli at 10 Hz), theta-burst stimulation (80% motor-threshold; rightDLPFC, continuous TBS, 1200 stimuli + leftDLPFC, intermittent TBS, 1200 stimuli), or sham TMS (N = 17, sham coil with the TBS protocol). Results. There was no significant effect in the primary outcome measures (change of the 21-item Hamilton Rating Scale for Depression). However, there was a tendency towards an increased responder rate at the end of the follow-up period for both active treatments as compared to sham, and this tendency was most pronounced for the TBS group. Conclusions. This pilot study did not reveal significant advantages of bilateral TBS or rTMS over sham treatment as an add-on treatment for major depression. A tendency towards a superior effect of bilateral TBS at the end of the follow-up period may warrant further studies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSCRANIAL MAGNETIC STIMULATION; TREATMENT-RESISTANT DEPRESSION; SHAM-CONTROLLED TRIALS; MAJOR DEPRESSION; DOUBLE-BLIND; ANTIDEPRESSANT EFFICACY; LOW-FREQUENCY; MOTOR CORTEX; METAANALYSIS; MULTISITE; depression; bilateral; theta burst; repetitive transcranial magnetic stimulation; prefrontal cortex |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Aug 2019 12:09 |
| Last Modified: | 02 Aug 2019 12:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/6355 |
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