Lang, Siegmund and Walter, Nike and Heidemanns, Stefanie and Lapa, Constantin and Schindler, Melanie and Krueckel, Jonas and Schmidt, Nils Ole and Hellwig, Dirk and Alt, Volker and Rupp, Markus (2024) [<SUP>18</SUP>F]FDG PET/CT Imaging Is Associated with Lower In-Hospital Mortality in Patients with Pyogenic Spondylodiscitis-A Registry-Based Analysis of 29,362 Cases. ANTIBIOTICS-BASEL, 13 (9): 860. ISSN 2079-6382,
Full text not available from this repository. (Request a copy)Abstract
Background: While MRI is the primary diagnostic tool for the diagnosis of spondylodiscitis, the role of [F-18]-fluorodeoxyglucose ([F-18]FDG) PET/CT is gaining prominence. This study aimed to determine the frequency of [F-18]FDG PET/CT usage and its impact on the in-hospital mortality rate in patients with spondylodiscitis, particularly in the geriatric population. Methods: We conducted a Germany-wide cross-sectional study from 2019 to 2021 using an open-access, Germany-wide database, analyzing cases with ICD-10 codes M46.2-, M46.3-, and M46.4- ('Osteomyelitis of vertebrae', 'Infection of intervertebral disc (pyogenic)', and 'Discitis unspecified'). Diagnostic modalities were compared for their association with in-hospital mortality, with a focus on [F-18]FDG PET/CT. Results: In total, 29,362 hospital admissions from 2019 to 2021 were analyzed. Of these, 60.1% were male and 39.9% were female, and 71.8% of the patients were aged 65 years and above. The overall in-hospital mortality rate was 6.5% for the entire cohort and 8.2% for the geriatric subgroup (p < 0.001). Contrast-enhanced (ce) MRI (48.1%) and native CT (39.4%) of the spine were the most frequently conducted diagnostic modalities. [F-18]FDG PET/CT was performed in 2.7% of cases. CeCT was associated with increased in-hospital mortality (OR = 2.03, 95% CI: 1.90-2.17, p < 0.001). Cases with documented [F-18]FDG PET/CT showed a lower frequency of in-hospital deaths (OR = 0.58, 95% CI: 0.18-0.50; p = 0.002). This finding was more pronounced in patients aged 65 and above (OR = 0.42, 95% CI: 0.27-0.65, p = 0.001). Conclusions: Despite its infrequent use, [F-18]FDG PET/CT was associated with a lower in-hospital mortality rate in patients with spondylodiscitis, particularly in the geriatric cohort. This study is limited by only considering data on hospitalized patients and relying on the assumption of error-free coding. Further research is needed to optimize diagnostic approaches for spondylodiscitis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACUTE KIDNEY INJURY; VERTEBRAL OSTEOMYELITIS; INFECTIOUS SPONDYLODISCITIS; COMPUTED-TOMOGRAPHY; DIAGNOSTIC-VALUE; BACTEREMIA; spondylodiscitis; vertebral osteomyelitis; [F-18]FDG PET/CT; in-hospital mortality; elderly patients |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Unfallchirurgie Medicine > Lehrstuhl für Neurochirurgie Medicine > Abteilung für Nuklearmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Jul 2025 06:15 |
| Last Modified: | 18 Jul 2025 06:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/63564 |
Actions (login required)
 |
View Item |
