Keller, Dennis and Mester, Patricia and Raeth, Ulrich and Krautbauer, Sabrina and Schmid, Stephan and Greifenberg, Verena and Mueller, Martina and Kunst, Claudia and Buechler, Christa and Pavel, Vlad (2024) Calprotectin, a Promising Serological Biomarker for the Early Diagnosis of Superinfections with Multidrug-Resistant Bacteria in Patients with COVID-19. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25 (17): 9294. ISSN 1661-6596, 1422-0067
Full text not available from this repository. (Request a copy)Abstract
Bacterial and fungal superinfections are common in COVID-19, and early diagnosis can enable timely intervention. Serum calprotectin levels increase with bacterial, fungal, and viral infections. This study evaluated serum calprotectin as a diagnostic and prognostic tool for microbial superinfections in COVID-19. Serum samples from adult patients with moderate and severe COVID-19 were collected during hospitalization from 2020 to 2024. Calprotectin levels were measured using an enzyme-linked immunosorbent assay in 63 patients with moderate COVID-19, 60 patients with severe COVID-19, and 34 healthy individuals. Calprotectin serum levels were elevated in patients with moderate COVID-19 compared with controls, and these levels were further increased in the severe cases. Patients with severe COVID-19 and vancomycin-resistant enterococci (VRE) bacteremia had elevated calprotectin levels, but their C-reactive protein and procalcitonin levels were not increased. Fungal superinfections and herpes simplex virus reactivation did not change the calprotectin levels. A calprotectin concentration of 31.29 mu g/mL can be used to diagnose VRE bloodstream infection with 60% sensitivity and 96% specificity. These data suggest that serum calprotectin may be a promising biomarker for the early detection of VRE bloodstream infections in patients with COVID-19.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MORTALITY; SEPSIS; DISCRIMINATE; NEUTROPHILS; S100A8/A9; COMPLEX; CELLS; calprotectin; biomarker; critical care; bloodstream infections; COVID-19 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Jul 2025 08:50 |
| Last Modified: | 18 Jul 2025 08:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/63567 |
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