Buelow, Sigrid and Ederer, Katharina U. and Holzinger, Jonas M. and Zeller, Lisa and Werner, Maren and Toelge, Martina and Pfab, Christina and Hirsch, Sarah and Goepferich, Franziska and Hiergeist, Andreas and Berberich-Siebelt, Friederike and Gessner, Andre (2024) Bactericidal/permeability-increasing protein instructs dendritic cells to elicit Th22 cell response. CELL REPORTS, 43 (3): 113929. ISSN 2211-1247,
Full text not available from this repository. (Request a copy)Abstract
Neutrophil-derived bactericidal/permeability-increasing protein (BPI) is known for its bactericidal activity against gram -negative bacteria and neutralization of lipopolysaccharide. Here, we define BPI as a potent activator of murine dendritic cells (DCs). As shown in GM-CSF-cultured, bone -marrow -derived cells (BMDCs), BPI induces a distinct stimulation profile including IL -2, IL -6, and tumor necrosis factor expression. Conventional DCs also respond to BPI, while M-CSF-cultivated or peritoneal lavage macrophages do not. Subsequent to BPI stimulation of BMDCs, CD4 + T cells predominantly secrete IL -22 and, when naive, preferentially differentiate into T helper 22 (Th22) cells. Congruent with the tissue -protective properties of IL -22 and along with impaired IL -22 induction, disease severity is significantly increased during dextran sodium sulfate -induced colitis in BPI -deficient mice. Importantly, physiological diversification of intestinal microbiota fosters BPI -dependent IL -22 induction in CD4 + T cells derived from mesenteric lymph nodes. In conclusion, BPI is a potent activator of DCs and consecutive Th22 cell differentiation with substantial relevance in intestinal homeostasis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IL-2 PRODUCTION; MOUSE; HOMEOSTASIS; EXPRESSION; ALARMIN; INFLAMMATION; ACTS; ACTIVATION; IMMUNITY; REVEALS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Jul 2025 08:15 |
| Last Modified: | 22 Jul 2025 08:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/63588 |
Actions (login required)
 |
View Item |
