Mester, Patricia and Raeth, Ulrich and Schmid, Stephan and Amend, Pablo and Keller, Dennis and Krautbauer, Sabrina and Bondarenko, Sofiia and Mueller, Martina and Buechler, Christa and Pavel, Vlad (2024) Serum Insulin-like Growth Factor-Binding Protein-2 as a Prognostic Factor for COVID-19 Severity. BIOMEDICINES, 12 (1): 125. ISSN , 2227-9059
Full text not available from this repository. (Request a copy)Abstract
Insulin-like growth factor-binding protein (IGFBP)-2 is a regulator of anabolic pathways, which become inactivated in severe illness. Here, we measured the serum IGFBP-2 levels of COVID-19 patients with moderate and severe disease as well as healthy controls to identify the associations of serum IGFBP-2 levels with disease severity. Patients with severe COVID-19 had higher serum IGFBP-2 levels than those with moderate disease and healthy controls, who had similar levels. Non-survivors of COVID-19 tended to have elevated serum IGFBP-2 levels compared to survivors. Increased serum IGFBP-2 levels were observed in patients requiring dialysis and vasopressor therapy. Serum IGFBP-2 was positively correlated with procalcitonin in both patient groups. Bacterial co-infection in severe COVID-19 patients did not influence serum IGFBP-2 levels. Patients with liver cirrhosis and obesity, showing increased and decreased serum IGFBP-2 levels, respectively, were excluded from the study. The present analysis showed that higher serum IGFBP-2 levels are associated with increased disease severity in COVID-19 patients. The similarity in serum IGFBP-2 levels between patients with moderate COVID-19 and healthy controls suggests that elevated IGFBP-2 is associated with critical illness rather than SARS-CoV-2 infection itself.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IGF-II; INFLAMMATORY RESPONSE; SEPSIS; IGFBP-2; AXIS; CARE; COVID-19; prognosis; IGFBP-2; intensive care; mortality; procalcitonin |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Jul 2025 10:03 |
| Last Modified: | 24 Jul 2025 10:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/63661 |
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