Bauswein, Markus and Zoubaa, Saida and Toelge, Martina and Eidenschink, Lisa and Riemenschneider, Markus J. and Neumann, Bernhard and Lee, De-Hyung and Eid, Ehab and Tappe, Dennis and Niller, Hans Helmut and Gessner, Andre and Schmidt, Barbara and Buelow, Sigrid and Angstwurm, Klemens (2024) Long-term Elevation of Complement Factors in Cerebrospinal Fluid of Patients With Borna Disease Virus 1 Encephalitis. JOURNAL OF INFECTIOUS DISEASES, 230 (4). e943-e953. ISSN 0022-1899, 1537-6613
Full text not available from this repository. (Request a copy)Abstract
Background Borna disease virus 1 (BoDV-1) causes rare but severe zoonotic infections in humans, presenting as encephalitis. The case-fatality risk is very high and no effective countermeasures have been established so far. An immunopathology is presumed, while data on immune responses in humans are limited. Evidence of a role of the complement system in various neurological disorders and in viral infections of the central nervous system is increasing and specific inhibitors are available as therapeutic options.Methods In this study, we investigated factors of the complement system in the cerebrospinal fluid (CSF) of patients with BoDV-1 infections (n = 17) in comparison to noninflammatory control CSF samples (n = 11), using a bead-based multiplex assay. In addition, immunohistochemistry was performed using postmortem brain tissue samples.Results We found an intrathecal elevation of complement factors of all complement pathways and an active cascade during human BoDV-1 infections. The increase of certain complement factors such as C1q was persistent, and C3 complement deposits were detected in postmortem brain sections. Intrathecal complement levels were negatively correlated with survival.Conclusions Further investigations are warranted to clarify whether targeting the complement cascade by specific inhibitors might be beneficial for patients suffering from severe BoDV-1 encephalitis. Complement factors are persistently elevated in cerebrospinal fluid of patients with Borna disease virus 1 encephalitis and are deposited in brain tissue. The activation of the complement system might impact the disease course and warrants further investigation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTIVIRAL ACTIVITY; RATS; PATHOGENESIS; ACTIVATION; EXPRESSION; BRAINS; SYSTEM; BoDV-1; zoonosis; complement system; immunopathogenesis; biomarkers |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Abteilung für Neuropathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Jul 2025 10:08 |
| Last Modified: | 24 Jul 2025 10:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/63665 |
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