Fabijanska, Malgorzata and Studzian, Kazimierz and Szmigiero, Leszek and Rybarczyk-Pirek, Agnieszka J. and Pfitzner, Arno and Cebula-Obrzut, Barbara and Smolewski, Piotr and Zyner, Elzbieta and Ochocki, Justyn (2015) trans-Platinum(II) complex of 3-aminoflavone - synthesis, X-ray crystal structure and biological activities in vitro. DALTON TRANSACTIONS, 44 (3). pp. 938-947. ISSN 1477-9226, 1477-9234
Full text not available from this repository. (Request a copy)Abstract
This paper describes the synthesis of trans-bis-(3-aminoflavone)dichloridoplatinum(II) (trans-Pt(3-af)(2)Cl-2; TCAP) for use as a potential anticancer compound, and the evaluation of its structure by elemental and spectral analyses, and X-ray crystallography. The complex demonstrated a significant cytotoxic effect against human and murine cancer cell lines, as well as weaker toxicity towards healthy cells (human peripheral blood lymphocytes) in comparison with cisplatin. Various biochemical and morphological methods confirm that the proapoptotic activity of trans-Pt(3-af)(2)Cl-2 is markedly higher than the reference cisplatin. Our results suggest that trans-Pt(3-af)(2)Cl-2 may have a different antitumour specificity from that of cisplatin.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SULFONAMIDE PLATINUM COMPLEXES; CIS-DDP; CIS-PT(II) COMPLEX; HYDROGEN-BONDS; COMET ASSAY; A549 CELLS; DERIVATIVES; GENOTOXICITY; LYMPHOCYTES; INDUCTION; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Anorganische Chemie > Chair Prof. Dr. Arno Pfitzner |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Aug 2019 07:13 |
| Last Modified: | 05 Aug 2019 07:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/6372 |
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