Kunzelmann, Karl and Ousingsawat, Jiraporn and Schreiber, Rainer (2024) Anoctamins in epithelial transport. CELL CALCIUM, 120: 102888. ISSN 0143-4160, 1532-1991
Full text not available from this repository. (Request a copy)Abstract
Plasma membrane localized anoctamin 1, 2 and 6 (TMEM16A, B, F) have been examined in great detail with respect to structure and function, but much less is known about the other seven intracellular members of this exciting family of proteins. This is probably due to their limited accessibility in intracellular membranous compartments, such as the endoplasmic reticulum (ER) or endosomes. However, these so-called intracellular anoctamins are also found in the plasma membrane (PM) which adds to the confusion regarding their cellular role. Probably all intracellular anoctamins except of ANO8 operate as intracellular phospholipid (PL) scramblases, allowing for Ca2+-activated, passive transport of phospholipids like phosphatidylserine between both membrane leaflets. Probably all of them also conduct ions, which is probably part of their physiological function. In this brief overview, we summarize key findings on the biological functions of ANO3, 4, 5, 7, 8, 9 and 10 (TMEM16C, D, E, G, H, J, K) that are gradually coming to light. Compartmentalized regulation of intracellular Ca2+ signals, tethering of the ER to specific PM contact sites, and control of intracellular vesicular trafficking appear to be some of the functions of intracellular anoctamins, while loss of function and abnormal expression are the cause for various diseases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | K+ CURRENTS; SCRAMBLASE ACTIVITY; POTASSIUM CHANNELS; CL-CHANNEL; CA2+; CALCIUM; CELL; CONDUCTANCE; FAMILY; ER; TMEM16C; TMEM16D; TMEM16E; TMEM16G; TMEM16H; TMEM16J; TMEM16K; ANO3; ANO4; ANO5; ANO7; ANO8; ANO9; ANO10; Dystonia; Chronic kidney disease; Calcium signaling |
| Subjects: | 500 Science > 500 Natural sciences & mathematics 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Karl Kunzelmann |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Jul 2025 07:51 |
| Last Modified: | 25 Jul 2025 07:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/63740 |
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