Baglio, Francesca and Griffanti, Ludovica and Saibene, Francesca Lea and Ricci, Cristian and Alberoni, Margherita and Critelli, Raffaella and Villanelli, Fabiana and Fioravanti, Raffaella and Mantovani, Federica and D'amico, Alessandra and Cabinio, Monia and Preti, Maria Giulia and Nemni, Raffaello and Farina, Elisabetta (2015) Multistimulation Group Therapy in Alzheimer's Disease Promotes Changes in Brain Functioning. NEUROREHABILITATION AND NEURAL REPAIR, 29 (1). pp. 13-24. ISSN 1545-9683, 1552-6844
Full text not available from this repository. (Request a copy)Abstract
Background. The growing social emergency represented by Alzheimer's disease (AD) and the lack of medical treatments able to modify the disease course have kindled the interest in nonpharmacological therapies. Objective. We introduced a novel nonpharmacological approach for people with AD (PWA) named Multidimensional Stimulation group Therapy (MST) to improve PWA condition in different disease domains: cognition, behavior, and motor functioning. Methods. Enrolling 60 PWA in a mild to moderate stage of the disease, we evaluated the efficacy of MST with a randomized-controlled study. Neuropsychological and neurobehavioral measures and functional magnetic resonance imaging (fMRI) data were considered as outcome measures. Results. The following significant intervention-related changes were observed: reduction in Neuropsychiatric Inventory scale score, improvement in language and memory subscales of Alzheimer's Disease Assessment Scale-Cognitive subscale, and increased fMRI activations in temporal brain areas, right insular cortex, and thalamus. Conclusions. Cognitive-behavioral and fMRI results support the notion that MST has significant effects in improving PWA cognitive-behavioral status by restoring neural functioning.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RANDOMIZED CONTROLLED-TRIAL; MILD COGNITIVE IMPAIRMENT; PSYCHOLOGICAL SYMPTOMS; DEMENTIA; STIMULATION; EXERCISE; EFFICACY; PEOPLE; CST; INTERVENTIONS; Alzheimer's disease; rehabilitation; occupational therapy; recreation therapy; cognitive therapy; magnetic resonance imaging; MRI; functional MRI; language |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Aug 2019 07:30 |
| Last Modified: | 05 Aug 2019 07:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/6378 |
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