Schmidtner, Niklas and Utrata, Alexander and Mester, Patricia and Schmid, Stephan and Mueller, Martina and Pavel, Vlad and Buechler, Christa (2024) Reduced Plasma Bone Morphogenetic Protein 6 Levels in Sepsis and Septic Shock Patients. BIOMEDICINES, 12 (8): 1682. ISSN , 2227-9059
Full text not available from this repository. (Request a copy)Abstract
Infectious diseases are associated with low iron levels and the induction of hepcidin, the primary protein regulating cellular iron export. Bone morphogenetic protein 6 (BMP6), a key regulator of hepcidin expression, has not yet been analyzed in the plasma of patients with systemic inflammatory response syndrome (SIRS) or sepsis. An analysis of 38 SIRS, 39 sepsis, and 78 septic shock patients revealed similar levels of BMP6 in sepsis and septic shock, which were lower compared to patients with SIRS and healthy controls. Plasma BMP6 levels did not correlate with procalcitonin and C-reactive protein levels in patients with SIRS or sepsis/septic shock. Neither bacterial nor SARS-CoV-2 infections affected plasma BMP6 levels. There was no difference in BMP6 levels between ventilated and non-ventilated patients, or between patients with and without dialysis. Vasopressor therapy did not alter BMP6 levels. Survivors had plasma BMP6 levels similar to non-survivors. Due to the high variability of plasma BMP6 levels, these analyses have limited clinical relevance. Iron, ferritin, and transferrin levels were known in at least 50% of patients but did not correlate with plasma BMP6 levels. In conclusion, this study showed normal BMP6 plasma levels in SIRS, which are reduced in patients with sepsis and septic shock. This suggests that the commonly observed increase in hepcidin levels and the decline in iron levels in SIRS, sepsis, and septic shock are not due to higher BMP6.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEPATIC HEPCIDIN EXPRESSION; IRON-METABOLISM; BMP6; REGULATOR; LIVER; septic shock; SIRS; COVID-19; C-reactive protein; survival; BMP6 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Jul 2025 08:28 |
| Last Modified: | 28 Jul 2025 08:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/63825 |
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