Bajraktari, Ganimete and Elger, Tanja and Huss, Muriel and Loibl, Johanna and Albert, Andreas and Kandulski, Arne and Mueller, Martina and Tews, Hauke Christian and Buechler, Christa (2024) Serum Galectin-3 as a Non-Invasive Marker for Primary Sclerosing Cholangitis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25 (9): 4765. ISSN 1661-6596, 1422-0067
Full text not available from this repository. (Request a copy)Abstract
Primary sclerosing cholangitis (PSC) is a serious liver disease associated with inflammatory bowel disease (IBD). Galectin-3, an inflammatory and fibrotic molecule, has elevated circulating levels in patients with chronic liver disease and inflammatory bowel disease (IBD). This study aims to clarify whether galectin-3 can differentiate between patients with IBD, PSC, and PSC-IBD. Our study measured serum galectin-3 levels in 38 healthy controls, 55 patients with IBD, and 22 patients with PSC (11 patients had underlying IBD and 11 patients did not), alongside the urinary galectin-3 of these patients and 18 controls. Serum and urinary galectin-3 levels in IBD patients were comparable to those in controls. Among IBD patients, those with high fecal calprotectin, indicating severe disease, exhibited lower serum and elevated urinary galectin-3 levels compared to those with low calprotectin levels. Serum galectin-3 levels were inversely correlated with C-reactive protein levels. PSC patients displayed higher serum and urinary galectin-3 levels than IBD patients, with the highest serum levels observed in PSC patients with coexisting IBD. There was no correlation between serum and urinary galectin-3 levels and laboratory indicators of liver injury in both IBD and PSC patients. In conclusion, this study demonstrates that serum and urinary galectin-3 levels can distinguish IBD from PSC patients, and also reveals higher serum galectin-3 levels in PSC-IBD patients compared to those with isolated PSC.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LIVER; EXPRESSION; FIBROSIS; INFLAMMATION; INSIGHTS; DISEASE; UPDATE; URINE; galectin-3; aminotransferase; calprotectin; urine; primary sclerosing cholangitis; inflammatory bowel disease |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Jul 2025 08:43 |
| Last Modified: | 28 Jul 2025 08:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/63828 |
Actions (login required)
 |
View Item |
