Hartmann, Valerie and Engelmann, Simon Udo and Pickl, Christoph and Haas, Maximilian and Kaelble, Sebastian and Gossler, Christopher and Eckl, Christoph and Hofmann, Aybike and Pichler, Renate and Burger, Maximilian and Mayr, Roman (2024) Impact of sarcopenia and fat distribution on outcomes in penile cancer. SCIENTIFIC REPORTS, 14 (1): 25422. ISSN 2045-2322,
Full text not available from this repository. (Request a copy)Abstract
Sarcopenia, defined as age-associated loss of skeletal muscle function and muscle mass, is a negative prognostic marker for survival in several tumor entities. However, data evaluating the impact of sarcopenia and fat distribution on penile cancer are rarely described. We performed a retrospective study including 38 patients who were diagnosed with squamous cell carcinoma of the penis. By measuring skeletal muscle mass and fat distribution at axial abdominal computed tomography images at the third lumbar vertebra several body composition parameters including skeletal muscle index (SMI), psoas muscle index (PMI), visceral obesity and visceral-to-subcutaneous fat ratio were determined. Among 38 patients, 26% (n = 10) of the patients with penile cancer were identified as sarcopenic. SMI, age, lymph node metastases, distant metastases and penile cancer of the shaft were identified as significant risk factors for overall survival. PMI and distant metastases were significantly associated with cancer specific survival. None of the analysed adipose tissue parameters could be identified as risk factors for survival in this study. We showed that sarcopenia occurs in a relevant part of patients with penile cancer and is a significant risk factor for overall survival (p = 0.032) and cancer specific survival (p = 0.034) for patients with penile cancer. Regarding fat distribution further studies are needed to evaluate its impact on sarcopenia and survival.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROGNOSTIC-SIGNIFICANCE; OBESITY; DEFINITION; CONSENSUS; Squamous carcinoma; Body composition; Skeletal muscle index; Psoas muscle index; Visceral obesity |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Jul 2025 11:09 |
| Last Modified: | 28 Jul 2025 11:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/63847 |
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