An inexpensive UV-LED photoacoustic based real-time sensor-system detecting exhaled trace-acetone

Pangerl, Jonas and Sukul, Pritam and Rueck, Thomas and Fuchs, Patricia and Weigl, Stefan and Miekisch, Wolfram and Bierl, Rudolf and Matysik, Frank-Michael (2024) An inexpensive UV-LED photoacoustic based real-time sensor-system detecting exhaled trace-acetone. PHOTOACOUSTICS, 38: 100604. ISSN 2213-5979

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Abstract

In this research we present a low-cost system for breath acetone analysis based on UV-LED photoacoustic spectroscopy. We considered the end-tidal phase of exhalation, which represents the systemic concentrations of volatile organic compounds (VOCs) - providing clinically relevant information about the human health. This is achieved via the development of a CO2-triggered breath sampling system, which collected alveolar breath over several minutes in sterile and inert containers. A real-time mass spectrometer is coupled to serve as a reference device for calibration measurements and subsequent breath analysis. The new sensor system provided a 3 sigma detection limit of 8.3 ppbV and an NNEA of 1.4E-9 Wcm(-1)Hz(-0.5). In terms of the performed breath analysis measurements, 12 out of 13 fell within the error margin of the photoacoustic measurement system, demonstrating the reliability of the measurements in the field.

Item Type: Article
Uncontrolled Keywords: BREATH ACETONE; Photoacoustic spectroscopy; Real-time mass-spectrometry; Breath analysis; Acetone; UV-LED
Subjects: 500 Science > 540 Chemistry & allied sciences
Divisions: Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Instrumentelle Analytik (Prof. Frank-Michael Matysik)
Depositing User: Dr. Gernot Deinzer
Date Deposited: 09 Dec 2025 09:36
Last Modified: 09 Dec 2025 09:36
URI: https://pred.uni-regensburg.de/id/eprint/63903

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