Wester, Michael and Koll, Franziska and Luedde, Mark and Langer, Christoph and Resch, Markus and Luchner, Andreas and Mueller, Karolina and Zeman, Florian and Koller, Michael and Maier, Lars S. and Sossalla, Samuel (2024) Predictors of symptom improvement in patients with chronic coronary syndrome after percutaneous coronary intervention. CLINICAL RESEARCH IN CARDIOLOGY, 113 (12). pp. 1757-1767. ISSN 1861-0684, 1861-0692
Full text not available from this repository. (Request a copy)Abstract
BackgroundDecreases in symptom load and improvements in quality of life are important goals in the invasive treatment of symptomatic chronic coronary syndrome (CCS). To date, it is not known which patients profit most from the invasive treatment.MethodsThis sub-analysis of the prospective, multi-centre PLA-pCi-EBO trial includes 145 patients with symptomatic CCS and successful PCI. The prespecified endpoints angina pectoris and quality of life (Seattle Angina Questionnaire-SAQ) were assessed 1 and 6 months after PCI. Predictors of symptom improvement were analyzed by logistic regression analysis.ResultsQuality of life, physical limitation, and angina frequency markedly improved 6 months after PCI. Worse baseline health status (i.e., low SAQ subscales) was the best predictor of highly clinically relevant improvements (>= 20 points in SAQ subscales) in symptom load and quality of life. Demographic factors (age, sex, body-mass index) and cardiovascular disease severity (number of involved vessels, ejection fraction) did not predict relevant improvements after PCI. The influence of psychologic traits has not previously been assessed. We found that neither optimism nor pessimism had a relevant effect on symptomatic outcome. However, patients who exercised more after PCI had a much larger improvement in quality of life despite no differences in physical limitation or angina frequency.ConclusionPCI effectively reduces symptom load and improves quality of life in patients with symptomatic CCS. Reduced baseline health status (symptom load, quality of life) are the only relevant predictors for improvements after PCI. Physical activity after PCI is associated with greater benefits for quality of life.Trial registryThe German Clinical Trials Register registration number is DRKS0001752.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OPTIMISM; ANGINA; PCI; CCS; Quality of life; Outcome |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Innere Medizin II Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Aug 2025 08:44 |
| Last Modified: | 26 Aug 2025 08:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/63947 |
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