Dittmar, David J. and Pielmeier, Franziska and Strieder, Nicholas and Fischer, Alexander and Herbst, Michael and Stanewsky, Hanna and Wenzl, Niklas and Roeseler, Eveline and Eder, Ruediger and Gebhard, Claudia and Schwarzfischer-Pfeilschifter, Lucia and Albrecht, Christin and Herr, Wolfgang and Edinger, Matthias and Hoffmann, Petra and Rehli, Michael (2024) Donor regulatory T cells rapidly adapt to recipient tissues to control murine acute graft-versus-host disease. NATURE COMMUNICATIONS, 15 (1): 3224. ISSN , 2041-1723
Full text not available from this repository. (Request a copy)Abstract
The adoptive transfer of regulatory T cells is a promising strategy to prevent graft-versus-host disease after allogeneic bone marrow transplantation. Here, we use a major histocompatibility complex-mismatched mouse model to follow the fate of in vitro expanded donor regulatory T cells upon migration to target organs. Employing comprehensive gene expression and repertoire profiling, we show that they retain their suppressive function and plasticity after transfer. Upon entering non-lymphoid tissues, donor regulatory T cells acquire organ-specific gene expression profiles resembling tissue-resident cells and activate hallmark suppressive and cytotoxic pathways, most evidently in the colon, when co-transplanted with graft-versus-host disease-inducing conventional T cells. Dominant T cell receptor clonotypes overlap between organs and across recipients and their relative abundance correlates with protection efficacy. Thus, this study reveals donor regulatory T cell selection and adaptation mechanisms in target organs and highlights protective features of Treg to guide the development of improved graft-versus-host disease prevention strategies. Graft-versus-Host disease is a major complication after allogeneic bone marrow transplantation and is ameliorated by adoptively transferred donor regulatory T cells. Here, the authors apply transcriptomic and TCR profiling to assess regulatory T cell organ-specific adaptation in murine bone marrow transplantation models.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MEDIATED SUPPRESSION; GRANZYME-B; TRANSPLANTATION; VIVO; EXPANSION; GVHD; SUBPOPULATION; TOLERANCE; INFUSION; SURVIVAL; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Jan 2026 06:56 |
| Last Modified: | 20 Jan 2026 06:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/63964 |
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