Klute, Lisa and Esser, Marie and Henssler, Leopold and Riedl, Moritz and Schindler, Melanie and Rupp, Markus and Alt, Volker and Kerschbaum, Maximilian and Lang, Siegmund (2024) Anterior Column Reconstruction of Destructive Vertebral Osteomyelitis at the Thoracolumbar Spine with an Expandable Vertebral Body Replacement Implant: A Retrospective, Monocentric Radiological Cohort Analysis of 24 Cases. JOURNAL OF CLINICAL MEDICINE, 13 (1): 296. ISSN , 2077-0383
Full text not available from this repository. (Request a copy)Abstract
Background: Vertebral osteomyelitis (VO) often necessitates surgical intervention due to bone loss-induced spinal instability. Anterior column reconstruction, utilizing expandable vertebral body replacement (VBR) implants, is a recognized approach to restore stability and prevent neurological compromise. Despite various techniques, clinical evidence regarding the safety and efficacy of these implants in VO remains limited. Methods: A retrospective cohort analysis, spanning 2000 to 2020, was conducted on 24 destructive VO cases at a Level 1 orthopedic trauma center. Diagnosis relied on clinical, radiological, and microbiological criteria. Patient demographics, clinical presentation, surgical interventions, and radiological outcomes were assessed. Results: The study included 24 patients (62.5% male; mean age 65.6 +/- 35.0 years), with 58% having healthcare-associated infections (HAVO). The mean radiological follow-up was 137.2 +/- 161.7 weeks. Surgical intervention significantly improved the bi-segmental kyphotic endplate angle (BKA) postoperatively (mean -1.4 degrees +/- 13.6 degrees). However, a noticeable loss of correction was observed over time. The study reported a mortality rate of 1/24. Conclusions: Anterior column reconstruction using expandable VBR effectively improved local spinal alignment in destructive VO. However, the study underscores the necessity for prolonged follow-up and continuous research to refine surgical techniques and postoperative care. Addressing long-term complications and refining surgical approaches will be pivotal as the field progresses.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PYOGENIC SPONDYLODISCITIS; LUMBAR SPINE; OPERATIVE TREATMENT; SURGICAL-TREATMENT; FRACTURES; INSTRUMENTATION; OUTCOMES; SURGERY; FUSION; WORK; expandable vertebral body replacement; vertebral osteomyelitis; bony fusion rate; anterior column reconstruction; spondylodiscitis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Unfallchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Jan 2026 07:11 |
| Last Modified: | 20 Jan 2026 07:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/63972 |
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