Spindler, Michael and Berneburg, Mark and Drexler, Konstantin and Kurz, Bernadett and Koegel, Julian and Niebel, Dennis (2025) Clinical variables and management of disseminated granuloma annulare - monocentric retrospective analysis of 33 cases between 2021 and 2023. DERMATOLOGIE, 76 (1). pp. 27-33. ISSN 2731-7005, 2731-7013
Full text not available from this repository. (Request a copy)Abstract
Background and objectives: Granuloma annulare (GA) is a noninfectious, granulomatous dermatosis that is generally localized and self-limiting. In 15% of cases, the disease disseminates with protracted trajectories. This study aims to characterise the patient population with disseminated GA at a German university hospital and to explore treatment modalities. Materials and methods: A retrospective monocentric evaluation was conducted at the University Hospital Regensburg between 2021 and 2023 with descriptive statistical analysis of the patient population and the treatment modalities used. Results: During the specified period, 239 patients with GA were identified, 33 of whom had histologically confirmed disseminated GA. Of the patients, 25 (76%) were women. Average age was 57.4 +/- 14.4 years. Furthermore 17 patients (53%) denied symptoms. Common symptoms included dysesthesia, itching and pain. Frequent concomitant diseases were diabetes mellitus, thyroid disease, atopic dermatitis and coronary heart disease. Topical glucocorticoids, systemic glucocorticoids, phototherapy, topical calcineurin inhibitors and dimethyl fumarate were used therapeutically in descending frequency. Only 6 patients (18%) showed partial or complete remission. Conclusion: Due to the lack of approved therapies, disseminated GA is treated with inadequately effective regimens. Prospective randomized placebo-controlled trials are needed to investigate the efficacy of novel targeted therapies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; Small molecules; Phototherapie; Granuloma annulare; Granulomatous disease; Biologicals; Phototherapy; Granulomatous disease; Biologicals; Phototherapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Mar 2026 08:19 |
| Last Modified: | 10 Mar 2026 08:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/63995 |
Actions (login required)
 |
View Item |
