Delacher, Michael and Schmidleithner, Lisa and Simon, Malte and Stueve, Philipp and Sanderink, Lieke and Hotz-Wagenblatt, Agnes and Wuttke, Marina and Schambeck, Kathrin and Ruhland, Brigitte and Hofmann, Veronika and Bittner, Sebastian and Ritter, Uwe and Pant, Asmita and Helbich, Sara Salome and Voss, Morten and Lemmermann, Niels A. W. and Bessiri-Schake, Lisa and Bohn, Toszka and Eigenberger, Andreas and Menevse, Ayse Nur and Gebhard, Claudia and Strieder, Nicholas and Abken, Hinrich and Rehli, Michael and Huehn, Jochen and Beckhoved, Philipp and Hehlgans, Thomas and Junger, Henrik and Geissler, Edward K. and Prantl, Lukas and Werner, Jens M. and Schmidl, Christian and Brors, Benedikt and Imbusch, Charles D. and Feuerer, Markus (2024) The effector program of human CD8 T cells supports tissue remodeling. JOURNAL OF EXPERIMENTAL MEDICINE, 221 (2): e20230488. ISSN 0022-1007, 1540-9538
Full text not available from this repository. (Request a copy)Abstract
This work reveals that human effector CD8 T cells not only mediate cytotoxicity but also promote tissue remodeling. The remodeling potential was demonstrated in different systems, including a primary organoid model and antigen-specific assays. CD8 T lymphocytes are classically viewed as cytotoxic T cells. Whether human CD8 T cells can, in parallel, induce a tissue regeneration program is poorly understood. Here, antigen-specific assay systems revealed that human CD8 T cells not only mediated cytotoxicity but also promoted tissue remodeling. Activated CD8 T cells could produce the epidermal growth factor receptor (EGFR)-ligand amphiregulin (AREG) and sensitize epithelial cells for enhanced regeneration potential. Blocking the EGFR or the effector cytokines IFN-gamma and TNF could inhibit tissue remodeling. This regenerative program enhanced tumor spheroid and stem cell-mediated organoid growth. Using single-cell gene expression analysis, we identified an AREG+, tissue-resident CD8 T cell population in skin and adipose tissue from patients undergoing abdominal wall or abdominoplasty surgery. These tissue-resident CD8 T cells showed a strong TCR clonal relation to blood PD1+TIGIT+ CD8 T cells with tissue remodeling abilities. These findings may help to understand the complex CD8 biology in tumors and could become relevant for the design of therapeutic T cell products.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFLAMMATION; LYMPHOCYTES; REPAIR; MACROPHAGES; SIGNATURES; IMMUNITY; RECEPTOR; LIGANDS; GROWTH; STATES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Jan 2026 12:23 |
| Last Modified: | 16 Jan 2026 12:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64038 |
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