Acs, Miklos and Herold, Zoltan and Neumann, Lea and Slowik, Przemyslaw and Evert, Katja and Gurok, Simon and Panczel, Ivan and Barna, Andras Jozsef and Dank, Magdolna and Szasz, Attila Marcell and Hornung, Matthias and Schlitt, Hans Jurgen and Werner, Jens M. (2024) Surgical Treatment and Outcome of Ovarian Cancer Patients With Liver Metastases: Experience of a Tertiary Hepatic and Peritoneal Surface Malignancy Center. ANTICANCER RESEARCH, 44 (2). pp. 731-741. ISSN 0250-7005, 1791-7530
Full text not available from this repository. (Request a copy)Abstract
Background/Aim: The aim of this study was to describe and evaluate the patterns, perioperative outcomes, and survival rates of patients subjected to hepatic resections for ovarian-derived liver metastasis as part of cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy (HIPEC). Furthermore, we investigated two subgroups of tumor patterns: hematogenous liver metastasis and infiltrative liver metastatic spread. Patients and Methods: A retrospective study was conducted. Patients from a University Tertiary Hepatic and Peritoneal Surface Malignancy Center with primary or recurrent ovarian cancer, who underwent liver resection as part of cytoreductive surgery between January 1992 and December 2022, were included. Results: Data from 35 patients were analyzed. Both median overall survival (OS) and diseasespecific survival (DSS) were 24.97 months. In a multivariate setting, the combined effect of age, peritoneal carcinomatosis index, body mass index, hematogenous liver metastasis vs. infiltrative spread types, and HIPEC (HR=0.2372; 95% CI=0.0719-0.7823; p=0.0181) over OS was tested. Survival analysis revealed no differences between the two metastatic spread types (OS: p=0.9720; DSS: p=0.9610). Younger age (p= 0.0301), splenectomy (p=0.0320), lesser omentectomy (p=0.0178), and right upper quadrant peritonectomy (p=0.0373) were more characteristic for those patients with infiltrative liver metastatic spread. Conclusion: Complete cytoreductive surgery, including hepatic resection is a feasible approach with or without additional HIPEC, which may provide survival benefit for patients with advanced and/ or recurrent ovarian cancer. If metastatic and infiltrative liver involvement is suspected, liver-specific imaging is recommended.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY; IV EPITHELIAL OVARIAN; CYTOREDUCTIVE SURGERY; FALLOPIAN-TUBE; RESECTION; CARCINOMA; IMPACT; TUMOR; Ovarian neoplasms; cytoreduction surgical procedures; hepatic metastasis; hepatic resection; hyperthermic intraperitoneal chemotherapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Jan 2026 10:05 |
| Last Modified: | 20 Jan 2026 10:05 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64082 |
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