Schuster, Antonia Margarete and Steines, Louisa and Banas, Bernhard and Bergler, Tobias (2024) Dickkopf 3 as a New Monitoring Tool for Kidney Function After Living Kidney Donation. JOURNAL OF CLINICAL MEDICINE, 13 (23): 7454. ISSN , 2077-0383
Full text not available from this repository. (Request a copy)Abstract
Background: Even today, a non-invasive biomarker to identify donors with enhanced risk for renal impairment is missing. Dickkopf 3 (DKK3) can cause tubulointerstitial fibrosis and is associated with rapid eGFR loss. The aim of our work was to analyze whether DKK3 can be used as a non-invasive alert marker for an increased risk of loss of kidney function in living kidney donors (LKDs). Methods: All donors who were examined between July 2022 and June 2023 (n = 117) were included. DKK3 was measured in the urine. The collected patient-related data were compared with parameters before donation. The study cohort was stratified by DKK3 values (</>= 200). Results: In the follow-up, 89 donors had a DKK3 value < 200 (group 1) and 28 donors had a DKK3 value >= 200 (group 2). During post-donation follow-up, renal function in group 1 was significantly better than that in group 2 (p = 0.01), although no difference in renal function before donation was detected (p = 0.84). Group 2 showed also a greater eGFR loss over time than group 1. Conclusions: LKDs with elevated DKK3 levels in the FU had impaired kidney function without evidence of increased risk factors pre-donation. DKK3 can represent a possible monitoring tool for kidney function in LKDs.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; DKK3; non-invasive monitoring; living kidney transplantation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Jan 2026 10:36 |
| Last Modified: | 20 Jan 2026 10:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64126 |
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