Immunomodulatory microbial metabolites as potential predictors of stem-cell transplantation outcomes

Orberg, Erik Thiele and Poeck, Hendrik (2024) Immunomodulatory microbial metabolites as potential predictors of stem-cell transplantation outcomes. [["eprint_typename_editorial" not defined]]

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Abstract

Microbiome diversity has been associated with improved outcomes after allogeneic stem-cell transplantation in patients with hematological cancers. Multimodal analysis of intestinal microbiome and metabolome data helped identify immunomodulatory microbial metabolites that were predictive of survival, transplant-related mortality and cancer relapse. These metabolites were products of short-chain-fatty-acid-synthesis pathways, and their associated genes were expressed by both bacterial species and bacteriophages.

Item Type: ["eprint_typename_editorial" not defined]
Uncontrolled Keywords: ;
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Depositing User: Dr. Gernot Deinzer
Date Deposited: 15 Sep 2025 07:26
Last Modified: 15 Sep 2025 07:26
URI: https://pred.uni-regensburg.de/id/eprint/64208

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