Schach, Christian and Koertl, Thomas and Zeman, Florian and Luttenberger, Bianca and Muehleck, Franziska and Baum, Paul and Lavall, Daniel and Vosshage, Nicola H. and Resch, Markus and Ripfel, Sarah and Meindl, Christine and Uecer, Ekrem and Hamer, Okka W. and Baessler, Andrea and Arzt, Michael and Koller, Michael and Sohns, Christian and Maier, Lars S. and Wachter, Rolf and Sossalla, Samuel (2024) Clinical Characterization of Arrhythmia-Induced Cardiomyopathy in Patients With Tachyarrhythmia and Idiopathic Heart Failure. JACC-CLINICAL ELECTROPHYSIOLOGY, 10 (5). pp. 870-881. ISSN 2405-500X, 2405-5018
Full text not available from this repository. (Request a copy)Abstract
Background Arrhythmia-induced cardiomyopathy (AIC) is a known entity, but prospective evidence for its characterization is limited. Objectives This study aimed to: 1) determine the relative frequency of the pure form of AIC in the clinically relevant cohort of patients with newly diagnosed, otherwise unexplained left ventricular systolic dysfunction (LVSD) and tachyarrhythmia; 2) assess the time to recovery from LVSD; and 3) identify parameters for an early diagnosis of AIC. Methods Patients were prospectively included, underwent effective rhythm restoration, and were followed-up at 2, 4, and 6 months to evaluate clinical characteristics, biomarkers, and cardiac imaging including cardiac magnetic resonance imaging. Patients with recurred arrhythmia were excluded from analysis. Results 41 of 50 patients were diagnosed with AIC 6 months after rhythm restoration. Left ventricular (LV) ejection fraction increased 2 months after rhythm restoration from 35.4% +/- 8.2% to 52.7% +/- 8.0% in AIC patients vs 37.0% +/- 9.5% to 43.3% +/- 7.0% in non-AIC patients. From month 2 to 6, LV ejection fraction continued to increase in AIC patients (57.2% +/- 6.1%; P < 0.001) but remained stable in non-AIC patients (44.0% +/- 7.8%; P = 0.628). Multivariable logistic regression analysis revealed that lower LV end-diastolic diameter at baseline could be used for early diagnosis of AIC, whereas biomarkers and other morphological or functional parameters, including late LV gadolinium enhancement, did not show suitability for early diagnosis. Conclusions We observed a high prevalence of AIC in patients with otherwise unexplained LVSD and concomitant tachyarrhythmia, suggesting that this condition may be underdiagnosed in clinical practice. Most patients recovered fast, within months, from LVSD. A low initial LV end-diastolic diameter may constitute an early marker for diagnosis of AIC.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ATRIAL-FIBRILLATION; CATHETER ABLATION; VENTRICULAR DYSFUNCTION; SYSTOLIC DYSFUNCTION; MECHANISMS; REVERSAL; RHYTHM; arrhythmia-induced cardiomyopathy; atrial fi brillation; left ventricular dysfunction; heart failure; tachycardiomyopathy; tachymyopathy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Röntgendiagnostik Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien Medicine > Universitäres Herzzentrum Regensburg (UHR) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Dec 2025 06:20 |
| Last Modified: | 04 Dec 2025 06:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64212 |
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