Yasoda-Mohan, Anusha and Adcock, Katherine and Leong, Sook Ling and Meade, Emma and Langguth, Berthold and Schecklmann, Martin and Lim, Hubert and Vanneste, Sven (2024) Tinnitus: A Dimensionally Segregated, yet Perceptually Integrated Heterogeneous Disorder. JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY, 25 (2). pp. 215-227. ISSN 1525-3961, 1438-7573
Full text not available from this repository. (Request a copy)Abstract
ObjectivesTinnitus subtypes are proposed to lie on a continuum of different symptom dimensions rather than be categorical. However, there is no comprehensive empirical data showing this complex relationship between different tinnitus symptoms. The objective of this study is to provide empirical evidence for the dimensional nature of tinnitus and how different auditory and non-auditory symptoms interact with each other through complex interactions. We do this using graph theory, a mathematical tool that empirically maps this complex interaction. This way, graph theory can be utilised to highlight a new and possibly important outlook on how we can understand the heterogeneous nature of tinnitus.DesignIn the current study, we use the screening databases of the Treatment Evaluation of Neuromodulation for Tinnitus-Stage A1 (TENT-A1) and A2 (TENT-A2) randomised trials to delineate the dimensional relationship between different clinical measures of tinnitus as a secondary data analysis. We first calculate the empirical relationship by computing the partial correlation. Following this, we use different measures of centrality to describe the contribution of different clinical measures to the overall network. We also calculate the stability of the network and compare the similarity and differences between TENT-A1 and TENT-A2.ResultsComponents of the auditory subnetwork (loudness discomfort level, sound sensitivity, average hearing loss and high frequency hearing loss) are highly inter-connected in both networks with sound sensitivity and loudness discomfort level being highly influential with high measures of centrality. Furthermore, the relationship between the densely connected auditory subnetwork with tinnitus-related distress seems to vary at different levels of distress, hearing loss, duration and age of the participants.ConclusionOur findings provide first-time evidence for tinnitus varying in a dimensional fashion illustrating the heterogeneity of this phantom percept and its ability to be perceptually integrated, yet behaviourally segregated on different symptomatic dimensions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PHANTOM SOUND; HEARING-LOSS; PREVALENCE; Tinnitus; Hyperacusis; Clinical signature; Diagnosis; Hearing loss |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Oct 2025 07:11 |
| Last Modified: | 07 Oct 2025 07:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64259 |
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