Straub, Josina and Baertl, Susanne and Verheul, Marielle and Walter, Nike and Wong, Ronald Man Yeung and Alt, Volker and Rupp, Markus (2024) Antimicrobial resistance: Biofilms, small colony variants, and intracellular bacteria. INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 55 (Suppl6): 111638. ISSN 0020-1383, 1879-0267
Full text not available from this repository. (Request a copy)Abstract
Soft tissue and bone infections continue to be a serious complication in orthopedic and trauma surgery. Both can lead to a high burden for the patients and the healthcare system. Musculoskeletal infections can be induced by intraoperative contamination, bacterial contamination of open wounds or hematogenous bacterial spread. During the recent decades, advances were achieved in the understanding of pathogenesis and antibiotic resistance. Despite some progress in the diagnosis and advancing of therapeutic concepts, groundbreaking successful improvement of treatment concepts is still missing. Current therapy concepts are based on the two pillars consisting of surgical debridement with joint or bone reconstruction as well as prolonged antibiotic therapy. An improved understanding of both host and pathogen-related factors leading to treatment failure is essential in musculoskeletal infections. Therefore, this review aims to give an overview of pathogen-related pathophysiology in musculoskeletal infections. It describes defense strategies of pathogens such as (1) biofilm, its development, characteristics, and treatment options. In addition, (2) characteristics of small colony variants and (3) intracellular bacteria are highlighted. Lastly (4) an outlook for potential and promising future therapeutic strategies is provided.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STAPHYLOCOCCUS-AUREUS; IMMUNE EVASION; INFECTIONS; PERSISTENT; BONE; FORM; DEFORMATION; PHENOTYPE; ADHERENCE; THERAPY; Antimicrobial resistance; Biofilm; Small colony variants; Intracellular bacteria |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Unfallchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Jan 2026 09:55 |
| Last Modified: | 22 Jan 2026 09:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64280 |
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