Oligonucleotide library screening for identification of virus-specific T-cell receptors

Welters, Marthe-Lina and Stadler, Serena and Anastasopoulou, Vasiliki and Bullinger, Lars and Leisegang, Matthias and Kammertoens, Thomas and Welters, Carlotta and Hansmann, Leo (2024) Oligonucleotide library screening for identification of virus-specific T-cell receptors. EUROPEAN JOURNAL OF IMMUNOLOGY, 54 (6). ISSN 0014-2980, 1521-4141

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Abstract

We demonstrate an optimized oligonucleotide library-based approach for the identification of virus-reactive T-cell receptors using Epstein-Barr virus as an example. HEK293T served as antigen-presenting cells and were co-cultured with human T cells that were transduced with T-cell receptors in question. T-cell activation was detected by CD137 expression. image

Item Type: Article
Uncontrolled Keywords: TARGET ANTIGENS; Epstein-Barr virus; Oligonucleotide library; Target epitope screening; T-cell immunology; TCR antigen identification
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Depositing User: Dr. Gernot Deinzer
Date Deposited: 14 Jan 2026 07:25
Last Modified: 14 Jan 2026 07:25
URI: https://pred.uni-regensburg.de/id/eprint/64284

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