Vega, Kimberly Benedetti and de Oliveira, Andre Luiz Carvalho and Koenig, Burkhard and Paixao, Marcio Weber (2024) Visible-Light-Induced Synthesis of 1,2-Dicarboxyl Compounds from Carbon Dioxide, Carbamoyl-dihydropyridine, and Styrene. ORGANIC LETTERS, 26 (4). pp. 860-865. ISSN 1523-7060, 1523-7052
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beta-Amidated carboxylic acids, or succinamic acid derivatives, constitute a valuable chemical scaffold with broad applications in pharmaceuticals, agrochemicals, and polymer sciences. Herein, we report a redox-neutral multicomponent reaction for the synthesis of succinamic acid derivatives in good yields. This protocol involves styrene, CO(2 )and 1,4-carbamoyl-dihydropyridine as radical precursors. The method exhibits a broad substrate scope under mild reaction conditions, including late-stage functionalization. Moreover, by employing (CO2)-C-13, the method enables the synthesis of labeled 1,2-dicarboxylic compounds.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Jul 2025 11:38 |
| Last Modified: | 29 Jul 2025 11:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64298 |
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