Simon, Malte and Stueve, Philipp and Schmidleithner, Lisa and Bittner, Sebastian and Beumer, Niklas and Strieder, Nicholas and Schmidl, Christian and Pant, Asmita and Gebhard, Claudia and Eigenberger, Andreas and Rehli, Michael and Prantl, Lukas and Hehlgans, Thomas and Brors, Benedikt and Imbusch, Charles D. and Delacher, Michael and Feuerer, Markus (2024) Single-cell chromatin accessibility and transposable element landscapes reveal shared features of tissue-residing immune cells. IMMUNITY, 57 (8). ISSN 1074-7613, 1097-4180
Full text not available from this repository. (Request a copy)Abstract
Tissue adaptation is required for regulatory T (Treg) cell function within organs. Whether this program shares aspects with other tissue-localized immune populations is unclear. Here, we analyzed single-cell chromatin accessibility data, including the transposable element (TE) landscape of CD45+ + immune cells from colon, skin, adipose tissue, and spleen. We identified features of organ-specific tissue adaptation across different immune cells. Focusing on tissue Treg cells, we found conservation of the Treg tissue adaptation program in other tissue-localized immune cells, such as amphiregulin-producing T helper (Th)17 cells. Accessible TEs can act as regulatory elements, but their contribution to tissue adaptation is not understood. TE landscape analysis revealed an enrichment of specific transcription factor binding motifs in TE regions within accessible chromatin peaks. TEs, specifically from the LTR family, were located in enhancer regions and associated with tissue adaptation. These findings broaden our understanding of immune tissue residency and provide an important step toward organ-specific immune interventions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | REGULATORY T-CELLS; TRANSCRIPTION-FACTOR; R PACKAGE; POPULATION; BATF; DIFFERENTIATION; HETEROGENEITY; ACCUMULATION; ENHANCERS; LINEAGE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Plastische-, Hand- und Wiederherstellungschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Jan 2026 12:41 |
| Last Modified: | 16 Jan 2026 12:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64302 |
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