Salameh, Luna Jammal and Bitzenhofer, Sebastian H. and Hanganu-Opatz, Ileana L. and Dutschmann, Mathias and Egger, Veronica (2024) Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels. SCIENCE, 383 (6682): eadk8511. 494-+. ISSN 0036-8075, 1095-9203
Full text not available from this repository. (Request a copy)Abstract
The transmission of the heartbeat through the cerebral vascular system causes intracranial pressure pulsations. We discovered that arterial pressure pulsations can directly modulate central neuronal activity. In a semi-intact rat brain preparation, vascular pressure pulsations elicited correlated local field oscillations in the olfactory bulb mitral cell layer. These oscillations did not require synaptic transmission but reflected baroreceptive transduction in mitral cells. This transduction was mediated by a fast excitatory mechanosensitive ion channel and modulated neuronal spiking activity. In awake animals, the heartbeat entrained the activity of a subset of olfactory bulb neurons within similar to 20 milliseconds. Thus, we propose that this fast, intrinsic interoceptive mechanism can modulate perception-for example, during arousal-within the olfactory bulb and possibly across various other brain areas.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RESPIRATORY MODULATION; SINGLE UNITS; PIEZO2; OSCILLATIONS; PERCEPTION; RESPONSES; STIMULATION; EXPRESSION; RHYTHMS; STRETCH; |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Neurophysiologie (Prof. Dr. Veronica Egger) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Sep 2025 09:50 |
| Last Modified: | 15 Sep 2025 09:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64309 |
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