Kiprova, Natalia and Desnoyers, Marine and Narobe, Rok and Klufts-Edel, Arthur and Chaud, Juliane and Koenig, Burkhard and Compain, Philippe and Kern, Nicolas (2024) Towards a General Access to 1-Azaspirocyclic Systems via Photoinduced, Reductive Decarboxylative Radical Cyclizations. CHEMISTRY-A EUROPEAN JOURNAL, 30 (13). e202303841. ISSN 0947-6539, 1521-3765
Full text not available from this repository. (Request a copy)Abstract
A simple yet versatile strategy for the construction of important 1-azaspirocyclic scaffolds is described. Alkynyl-tethered N-hydroxyphthalimide esters, swiftly assembled through an alkylation/deprotection/activation sequence, undergo photoinduced reductive decarboxylative radical 5-exo and 6-exo-dig cyclizations employing eosin Y (EY) as inexpensive photocatalyst. The key step can proceed in a diastereoconvergent manner and affords diverse ring systems relevant to medicinal chemistry and natural products.+image
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BOND-DISSOCIATION ENERGIES; ELECTRON-TRANSFER; METAL-FREE; RING-CLOSURE; EOSIN Y; VINYL; CONSTRUCTION; RULES; N-(ACYLOXY)PHTHALIMIDES; STEREOCHEMISTRY; azaspirocycles; radicals; alkynes; decarboxylation; photoredox |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Jan 2026 05:52 |
| Last Modified: | 14 Jan 2026 05:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64373 |
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