Einhauser, Sebastian and Asam, Claudia and Weps, Manuela and Senninger, Antonia and Peterhoff, David and Bauernfeind, Stilla and Asbach, Benedikt and Carnell, George William and Heeney, Jonathan Luke and Wytopil, Monika and Fuchs, Andre and Messmann, Helmut and Prelog, Martina and Liese, Johannes and Jeske, Samuel D. and Protzer, Ulrike and Hoelscher, Michael and Geldmacher, Christof and Ueberla, Klaus and Steininger, Philipp and Wagner, Ralf (2024) Longitudinal effects of SARS-CoV-2 breakthrough infection on imprinting of neutralizing antibody responses. EBIOMEDICINE, 110: 105438. ISSN 2352-3964
Full text not available from this repository. (Request a copy)Abstract
Background The impact of the infecting SARS-CoV-2 variant of concern (VOC) and the vaccination status was determined on the magnitude, breadth, and durability of the neutralizing antibody (nAb) profile in a longitudinal multicentre cohort study. Methods 173 vaccinated and 56 non-vaccinated individuals were enrolled after SARS-CoV-2 Alpha, Delta, or Omicron infection and visited four times within 6 months and nAbs were measured for D614G, Alpha, Delta, BA.1, BA.2, BA.5, BQ.1.1, XBB.1.5 and JN.1. Findings Magnitude-breadth-analysis showed enhanced neutralization capacity in vaccinated individuals against multiple VOCs. Longitudinal analysis revealed sustained neutralization magnitude-breadth after antigenically distant Delta or Omicron breakthrough infection (BTI), with triple-vaccinated individuals showing significantly elevated titres and improved breadth. Antigenic mapping and antibody landscaping revealed initial boosting of vaccine-induced WT- specific responses after BTI, a shift in neutralization towards infecting VOCs at peak responses and an immune imprinted bias towards dominating WT immunity in the long-term. Despite that bias, machine-learning models confirmed a sustained shift of the immune-profiles following BTI. Interpretation In summary, our longitudinal analysis revealed delayed and short lived nAb shifts towards the infecting VOC, but an immune imprinted bias towards long-term vaccine induced immunity after BTI.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MAGNITUDE; BREADTH; SIN |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Abteilung für Krankenhaushygiene und Infektiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Jan 2026 06:40 |
| Last Modified: | 14 Jan 2026 06:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64385 |
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