Klotz, Laura V. and Zimmermann, Julia and Mueller, Karolina and Kovacs, Julia and Hassan, Mohamed and Koller, Michael and Schmid, Severin and Huppertz, Gunnar and Markowiak, Till and Passlick, Bernward and Hofmann, Hans-Stefan and Winter, Hauke and Hatz, Rudolf A. and Eichhorn, Martin E. and Ried, Michael (2024) Multimodal Treatment of Pleural Mesothelioma with Cytoreductive Surgery and Hyperthermic Intrathoracic Chemotherapy: Impact of Additive Chemotherapy. CANCERS, 16 (8): 1587. ISSN 2072-6694
Full text not available from this repository. (Request a copy)Abstract
Simple Summary Cytoreductive surgery combined with intraoperative hyperthermic chemoperfusion (HITOC) within a multimodal treatment approach has a positive impact on the survival of highly selected patients with epithelioid pleural mesothelioma. The addition of chemotherapy significantly affects the interval to tumor recurrence.Abstract Cytoreductive surgery (CRS) combined with hyperthermic intrathoracic chemoperfusion (HITOC) is a promising treatment strategy for pleural mesothelioma (PM). The aim of this study was to evaluate the impacts of this multimodal approach in combination with systemic treatment on disease-free survival (DFS) and overall survival (OS). In this retrospective multicenter study, clinical data from patients after CRS and HITOC for PM at four high-volume thoracic surgery departments in Germany were analyzed. A total of 260 patients with MPM (220 epithelioid, 40 non-epithelioid) underwent CRS and HITOC as part of a multimodal treatment approach. HITOC was administered with cisplatin alone (58.5%) or cisplatin and doxorubicin (41.5%). In addition, 52.1% of patients received neoadjuvant and/or adjuvant chemotherapy. The median follow-up was 48 months (IQR = 38 to 58 months). In-hospital mortality was 3.5%. Both the resection status (macroscopic complete vs. incomplete resection) and histologic subtype (epithelioid vs. non-epithelioid) had significant impacts on DFS and OS. In addition, adjuvant chemotherapy (neoadjuvant/adjuvant) significantly increased DFS (p = 0.003). CRS and HITOC within a multimodal treatment approach had positive impacts on the survival of patients with epithelioid PM after macroscopic complete resection. The addition of chemotherapy significantly prolonged the time to tumor recurrence or progression.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EXTRAPLEURAL PNEUMONECTOMY; PLEURECTOMY DECORTICATION; EXTENDED PLEURECTOMY; RADICAL SURGERY; METAANALYSIS; MULTICENTER; SURVIVAL; THERAPY; pleural mesothelioma; chemoperfusion; cytoreductive surgery; cisplatin; thoracic surgery; multimodal; decortication |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Thoraxchirurgie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Jan 2026 06:45 |
| Last Modified: | 22 Jan 2026 06:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64389 |
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