Papathemelis, Thomas and Ortmann, Olaf and Kohl, Cynthia and Neuser, Petra and Tol, Kees Kleihues-van and Klinkhammer-Schalke, Monika and Ugocsai, Peter and Walter, Christina Barbara and Rottmann, Miriam and Real, Catherine and Justenhoven, Christina and Robers, Gabriele and Schneider, Constanze and Gerken, Michael and Sackmann, Andrea and Kim-Wanner, Soo-Zin (2024) Treatment of endometrial cancer from 2000 to 2020 in Germany: a retrospective population based cohort study. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 150 (5): 279. ISSN 0171-5216, 1432-1335
Full text not available from this repository. (Request a copy)Abstract
Purpose Endometrial cancer (EC) is one of the most common malignancies among women in western countries. This study aimed to assess data on patient treatment in Germany throughout two decades to evaluate the development and effect of surgery, radiation, and chemotherapy.Methods This retrospective registry study included 34,349 EC patients diagnosed between 2000 and 2020. Patients were classified into five risk groups. Overall survival was analyzed by Kaplan-Meier method as well as univariable and multivariable Cox regression to evaluate risk factors and treatment options.Results Over the study period, minimal invasive surgery was used more often compared to open surgery and was associated with better overall survival. Patients with advanced EC were more likely to receive multimodal therapy. Patients with intermediate risk EC had a good prognosis upon surgery, which further improved when radiotherapy was added. High-risk patients showed poorer prognosis but clearly benefited from additional radiotherapy. Survival of elderly high-risk patients with a non-endometrioid histology was improved when chemotherapy was added to surgery and radiotherapy.Results Over the study period, minimal invasive surgery was used more often compared to open surgery and was associated with better overall survival. Patients with advanced EC were more likely to receive multimodal therapy. Patients with intermediate risk EC had a good prognosis upon surgery, which further improved when radiotherapy was added. High-risk patients showed poorer prognosis but clearly benefited from additional radiotherapy. Survival of elderly high-risk patients with a non-endometrioid histology was improved when chemotherapy was added to surgery and radiotherapy.Conclusion Our study includes a large analysis of data from German clinical cancer registries on the care of endometrial cancer during two decades. We observed an increase of minimal invasive surgery. There is evidence that minimal invasive surgery is not inferior to open surgery. Adjuvant radio- and chemotherapy further improves survival depending on risk group and age.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PELVIC RADIATION-THERAPY; RADICAL HYSTERECTOMY; RANDOMIZED-TRIAL; FOLLOW-UP; CARCINOMA; STAGE; CHEMOTHERAPY; CERVIX; Overall survival; Outcome; Multimodal therapy; Surgery; Radiotherapy; Chemotherapy; Retrospective cohort study |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) Medicine > Zentren des Universitätsklinikums Regensburg > Tumorzentrum e.V. |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Jan 2026 11:43 |
| Last Modified: | 16 Jan 2026 11:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64404 |
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