Pal, Adwitiya and Mondal, Bijan and Sau, Subham and De, Soumita and Thakur, Arunabha (2024) Visible Light-Mediated Co(II) Catalyzed Synthesis of α,β-Epoxy Ketones by Oxidative Coupling of Alkenes and Aldehydes in Water. ORGANIC LETTERS, 26 (38). pp. 8183-8187. ISSN 1523-7060, 1523-7052
Full text not available from this repository. (Request a copy)Abstract
A one-step, two-component visible light-mediated CoCl2<middle dot>6H(2)O-catalyzed oxidative acylation of alkenes by aldehydes to synthesize alpha,beta-epoxy ketone has been achieved in water at room temperature. The photocatalytic activity of Co(II) presented a remarkable achievement for synthesis of alpha,beta-epoxy ketones from aldehydes and olefins, with a wide substrate compatibility including aromatic, heteroaromatic and aliphatic aldehydes, styrenes with both electron-donating and withdrawing groups, alpha-substituted styrenes, stilbene, acrylates, and even the challenging unactivated aliphatic alkenes. Mechanistic studies including radical trapping experiments, intermediate detection by GCMS, Hammett analysis, and DFT studies unveil the nature of the photocatalytic pathway.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ONE-POT SYNTHESIS; ASYMMETRIC EPOXIDATION; BENZALDEHYDES; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Anorganische Chemie > Chair Prof. Dr. Manfred Scheer |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Oct 2025 06:42 |
| Last Modified: | 08 Oct 2025 06:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64435 |
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