Schoenmehl, Rebecca and Mendelsohn, Daniel H. and Winter, Lina and Pabel, Steffen and Niedermair, Tanja and Evert, Katja and Cheung, Wing-Hoi and Wong, Ronald Man Yeung and Schmitt, Volker H. and Keller, Karsten and Barsch, Friedrich and Dietl, Alexander and Gummert, Jan F. and Schramm, Rene and Sossalla, Samuel and Brochhausen, Christoph (2024) Comparative Analysis of Mitochondria Surrounding the Intercalated Discs in Heart Diseases-An Ultrastructural Pilot Study. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25 (14): 7644. ISSN 1661-6596, 1422-0067
Full text not available from this repository. (Request a copy)Abstract
Background: Mitochondria play a crucial role in adapting to fluctuating energy demands, particularly in various heart diseases. This study investigates mitochondrial morphology near intercalated discs in left ventricular (LV) heart tissues, comparing samples from patients with sinus rhythm (SR), atrial fibrillation (AF), dilated cardiomyopathy (DCM), and ischemic cardiomyopathy (ICM). Methods: Transmission electron microscopy was used to analyze mitochondria within 0-3.5 mu m and 3.5-7 mu m of intercalated discs in 9 SR, 10 AF, 9 DCM, and 8 ICM patient samples. Parameters included mean size in mu m2 and elongation, count, percental mitochondrial area in the measuring frame, and a conglomeration score. Results: AF patients exhibited higher counts of small mitochondria in the LV myocardium, resembling SR. DCM and ICM groups had fewer, larger, and often hydropic mitochondria. Accumulation rates and percental mitochondrial area were similar across groups. Significant positive correlations existed between other defects/size and hydropic mitochondria and between count/area and conglomeration score, while negative correlations between count and size/other defects and between hydropic mitochondria and count could be seen as well. Conclusion: Mitochondrial parameters in the LV myocardium of AF patients were similar to those of SR patients, while DCM and ICM displayed distinct changes, including a decrease in number, an increase in size, and compromised mitochondrial morphology. Further research is needed to fully elucidate the pathophysiological role of mitochondrial morphology in different heart diseases, providing deeper insights into potential therapeutic targets and interventions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ATRIAL-FIBRILLATION; CATHETER ABLATION; DYSFUNCTION; mitochondria; electron microscopy; ultrastructure; cardiomyopathy; atrial fibrillation; intercalated disc |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Jan 2026 13:43 |
| Last Modified: | 26 Jan 2026 13:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64445 |
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