Abken, Hinrich (2024) Transforming the Dark into Light: A Siglec-9 Switch. CANCER IMMUNOLOGY RESEARCH, 12 (10). p. 1310. ISSN 2326-6066, 2326-6074
Full text not available from this repository. (Request a copy)Abstract
Tumor-associated immune repression dampens the success of T-cell therapy for cancer by a plethora of inhibitory mechanisms including aberrant glycosylation. In this issue, Eisenberg and colleagues show that IFN gamma induces hyper-sialylation of cancer cells and that this acts as the "checkpoint" through binding to the inhibitory molecule Siglec-9 on immune cells. A chimeric Siglec-9 "switch" receptor converts the suppressive signal into a stimulatory signal, thereby restoring T-cell responses in the tumor tissue, which has multiple implications for the use of adoptive cell therapy in cancer. See related article by Eisenberg et al., p. 1380 (3)
| Item Type: | Article |
|---|---|
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Oct 2025 05:37 |
| Last Modified: | 21 Oct 2025 05:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64476 |
Actions (login required)
 |
View Item |
