Schrod, Stefan and Lueck, Niklas and Lohmayer, Robert and Solbrig, Stefan and Voelkl, Dennis and Wipfler, Tina and Shutta, Katherine H. and Ben Guebila, Marouen and Schaefer, Andreas and Beissbarth, Tim and Zacharias, Helena U. and Oefner, Peter J. and Quackenbush, John and Altenbuchinger, Michael (2024) Spatial Cellular Networks from omics data with SpaCeNet. GENOME RESEARCH, 34 (9). pp. 1371-1383. ISSN 1088-9051, 1549-5469
Full text not available from this repository. (Request a copy)Abstract
Advances in omics technologies have allowed spatially resolved molecular profiling of single cells, providing a window not only into the diversity and distribution of cell types within a tissue, but also into the effects of interactions between cells in shaping the transcriptional landscape. Cells send chemical and mechanical signals which are received by other cells, where they can subsequently initiate context-specific gene regulatory responses. These interactions and their responses shape the individual molecular phenotype of a cell in a given microenvironment. RNAs or proteins measured in individual cells, together with the cells' spatial distribution, provide invaluable information about these mechanisms and the regulation of genes beyond processes occurring independently in each individual cell. "SpaCeNet" is a method designed to elucidate both the intracellular molecular networks (how molecular variables affect each other within the cell) and the intercellular molecular networks (how cells affect molecular variables in their neighbors). This is achieved by estimating conditional independence (CI) relations between captured variables within individual cells and by disentangling these from CI relations between variables of different cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ENDOTHELIAL GROWTH-FACTOR; GENE-EXPRESSION; OLIGODENDROCYTE; SELECTION; REVEALS; PROTEIN; ATLAS; CELLS; SEQ; |
| Subjects: | 500 Science > 530 Physics 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner) Physics > Institute of Theroretical Physics > Chair Professor Schäfer > Group Andreas Schäfer |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Jan 2026 14:02 |
| Last Modified: | 26 Jan 2026 14:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64499 |
Actions (login required)
 |
View Item |
