Bleck, Dennis and Loacker-Schoech, Klara and Classen, Tim and Jose, Joachim and Schneider, Matthias and Pongratz, Georg (2024) Fibroblast-like synoviocytes preferentially induce terminal differentiation of IgD<SUP>+</SUP> memory B cells instead of naïve B cells. IMMUNOLOGY, 173 (3). pp. 520-535. ISSN 0019-2805, 1365-2567
Full text not available from this repository. (Request a copy)Abstract
Rheumatoid arthritis (RA) is a systemic autoimmune disease driven by highly active autoantibody-producing B cells. Activation of B cells is maintained within ectopic germinal centres found in affected joints. Fibroblast-like synoviocytes (FLS) present in inflamed joints support B-cell survival, activation, and differentiation. CD27+ memory B cells and naive B cells show very different responses to activation, particularly by CD40 ligand (CD40L). We show that FLS-dependent activation of human B cells is dependent on interleukin-6 (IL-6) and CD40L. FLS have been shown to activate both naive and memory B cells. Whether the activating potential of FLS is different for naive and memory B cells has not been investigated. Our results suggest that FLS-induced activation of B cells is dependent on IL-6 and CD40L. While FLS are able to induce plasma cell differentiation, isotype switching, and antibody production in memory B cells, the ability of FLS to activate naive B cells is significantly lower.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LIVED PLASMA-CELLS; RHEUMATOID-ARTHRITIS; GERMINAL CENTER; SYNOVIAL FIBROBLASTS; CD40 LIGAND; IL-6; EXPRESSION; INTERLEUKIN-6; RECEPTOR; THERAPY; autoimmunity; auto-inflammation; B cells; CD40 ligand; fibroblast-like synoviocytes; interleukin 6; rheumatoid arthritis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Jan 2026 07:43 |
| Last Modified: | 14 Jan 2026 07:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64516 |
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