Grundler, Elena and Gerken, Michael and Schatz, Sabine and Dittrich, Luca and Biebl, Matthias and Rink, Andreas D. and Kneist, Werner and Aigner, Felix and Voelkel, Vinzenz and Fuerst, Alois (2024) Transanal total mesorectal excision: short- and long-term results of four certified colorectal cancer centers in Germany. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 39 (1): 132. ISSN 0179-1958, 1432-1262
Full text not available from this repository.Abstract
BackgroundTransanal total mesorectal excision (TaTME), a novel approach for treating low rectal cancer, holds promise. However, concerns exist in certain countries about their oncologic safety due to less-than-optimal outcomes on global studies. This research seeks to evaluate the long-term oncologic outcomes focusing on local recurrence rate and overall survival after TaTME surgery in Germany.Patients and methodsThis study analyzed data from patients who underwent elective TaTME surgery between 2014 and 2021 in four certified colorectal cancer centers in Germany. Primary endpoints were 3-year local recurrence rate and local recurrence-free survival (LRFS). Secondary outcomes encompassed overall survival (OS), operative time, completeness of local tumor resection, lymph node resection, and postoperative complications.ResultsA total of 378 patients were analyzed (mean age 61.6 years; 272 males, 72%). After a median follow-up period of 2.5 years, 326 patients with UICC-stages I-III and tumor operability included in survival analyses. Local recurrence was observed in 8 individuals, leading to a 3-year cumulative local recurrence rate of 2.2% and a 3-year LRFS rate of 88.1%. The 3-year OS rate stood at 88.9%. Within 30 days after surgery, anastomotic leakage occurred in 19 cases (5%), whereas a presacral abscess was present in 12 patients (3.2%).ConclusionTaTME proves effective in addressing the anatomical and technical challenges of low rectal surgery and is associated with pleasing short- and long-term results. However, its safe integration into surgical routine necessitates sufficient knowledge and a previously completed training program.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CLASSIFICATION; COMPLICATIONS; SURGERY; Rectal cancer; Transanal total mesorectal excision; Short-term outcome; Long-term outcome; Oncologic safety |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Zentren des Universitätsklinikums Regensburg > Tumorzentrum e.V. |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Jan 2026 10:17 |
| Last Modified: | 13 Jan 2026 10:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64535 |
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