Fererberger, Tanja and Buechler, Christa and Kandulski, Arne and Elger, Tanja and Loibl, Johanna and Schmid, Stephan and Sommersberger, Stefanie and Gunawan, Stefan and Zundler, Sebastian and Huss, Muriel and Bettenworth, Dominik and Kempa, Sally and Weidlich, Simon and Foeh, Bandik and Huang, Xinyu and Grzegorzek, Marcin and Derer-Petersen, Stefanie and Guenther, Ulrich L. and Marquardt, Jens U. and Kunst, Claudia and Guelow, Karsten and Mueller, Martina and Sina, Christian and Schmelter, Franziska and Tews, Hauke C. (2024) Distinct metabolomic and lipidomic profiles in serum samples of patients with primary sclerosing cholangitis. FRONTIERS IN MEDICINE, 11: 1334865. ISSN , 2296-858X
Full text not available from this repository. (Request a copy)Abstract
Intoduction Identification of specific metabolome and lipidome profile of patients with primary sclerosing cholangitis (PSC) is crucial for diagnosis, targeted personalized therapy, and more accurate risk stratification.Methods Nuclear magnetic resonance (NMR) spectroscopy revealed an altered metabolome and lipidome of 33 patients with PSC [24 patients with inflammatory bowel disease (IBD) and 9 patients without IBD] compared with 40 age-, sex-, and body mass index (BMI)-matched healthy controls (HC) as well as 64 patients with IBD and other extraintestinal manifestations (EIM) but without PSC.Results In particular, higher concentrations of pyruvic acid and several lipoprotein subfractions were measured in PSC in comparison to HC. Of clinical relevance, a specific amino acid and lipid profile was determined in PSC compared with IBD and other EIM.Discussion These results have the potential to improve diagnosis by differentiating PSC patients from HC and those with IBD and EIM.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFLAMMATORY-BOWEL-DISEASE; PRIMARY BILIARY-CIRRHOSIS; RISK-FACTORS; INSULIN-RESISTANCE; CHOLANGIOCARCINOMA; CHOLANGIOGRAPHY; LIPOPROTEINS; PATHOGENESIS; ASSOCIATION; GENETICS; PSC; IBD; NMR; metabolome; lipidome |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Plastische-, Hand- und Wiederherstellungschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Jan 2026 14:37 |
| Last Modified: | 26 Jan 2026 14:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64562 |
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