Owen, Amber R. and Farias, Ana and Levins, Anne-Marie and Wang, Ziyin and Higham, Sophie L. and Mack, Matthias and Tregoning, John S. and Johansson, Cecilia (2024) Exposure to bacterial PAMPs before RSV infection exacerbates innate inflammation and disease via IL-1α and TNF-α. MUCOSAL IMMUNOLOGY, 17 (6). pp. 1184-1198. ISSN 1933-0219, 1935-3456
Full text not available from this repository. (Request a copy)Abstract
Respiratory syncytial virus (RSV) can cause severe lower respiratory tract infections. Understanding why some individuals get more serious disease may help with diagnosis and treatment. One possible risk factor underlying severe disease is bacterial exposure before RSV infection. Bacterial exposure has been associated with increased respiratory viral-induced disease severity but the mechanism remains unknown. Respiratory bacterial infections or exposure to their pathogen associated molecular patterns (PAMPs) trigger innate immune inflammation, characterised by neutrophil and inflammatory monocyte recruitment and the production of inflammatory cytokines. We hypothesise that these changes to the lung environment alter the immune response and disease severity during subsequent RSV infection. To test this, we intranasally exposed mice to LPS, LTA or Acinetobacter baumannii (an airway bacterial pathogen) before RSV infection and observed an early induction of disease, measured by weight loss, at days 1-3 after infection. Neutrophils or inflammatory monocytes were not responsible for driving this exacerbated weight loss. Instead, exacerbated disease was associated with increased IL-1 alpha and TNF-alpha, which orchestrated the recruitment of innate immune cells into the lung. This study shows that exposure to bacterial PAMPs prior to RSV infection increases the expression of IL-1 alpha and TNF-alpha, which dysregulate the immune response resulting in exacerbated disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RESPIRATORY-SYNCYTIAL-VIRUS; ACINETOBACTER-BAUMANNII; SIGNAL-TRANSDUCTION; IMMUNE-RESPONSES; EPITHELIAL-CELLS; T-CELLS; LUNG; NEUTROPHIL; BLOOD; BRONCHIOLITIS; Respiratory infections; Virus infections; Pro-inflammatory cytokines; Innate immunity; Bacteria |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Jan 2026 09:32 |
| Last Modified: | 27 Jan 2026 09:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64587 |
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