Klobuch, Sebastian and Weber, Daniela and Holler, Barbara and Herr, Wolfgang and Holler, Ernst and Wolff, Daniel (2017) Potential Role of the PD-1/PD-L1 Axis in the Immune Regulation of Chronic GVHD. ONCOLOGY RESEARCH AND TREATMENT, 40 (7-8). pp. 447-450. ISSN 2296-5270, 2296-5262
Full text not available from this repository. (Request a copy)Abstract
Background: Antibodies blocking the PD-1/PD-L1 axis have been shown to have substantial antitumor effects also in the treatment of Hodgkin's lymphoma (HL) relapsing after conventional chemotherapy or even autologous hematopoietic stem cell transplantation (autoHSCT). In the case of allogeneic HSCT (alloHSCT), this treatment bears the risk of inducing graft-versus-host disease (GVHD). So far, only a small number of patients who developed acute GVHD after PD-1 antibody administration are described in the literature. Case Reports: We herein report the cases of 2 HL patients after alloHSCT who both responded well to the therapy; however, 1 patient developed chronic GVHD (cGVHD) within 3 days of administration of nivolumab. This patient already had a history of cGVHD and interestingly showed manifestations at the very same sites. The other patient never showed any signs of cGVHD, even with the administration of 13 cycles of anti-PD-1 therapy and large doses of donor lymphocytes. Conclusion: The rapid reappearance of cGVHD after blockade of PD-1 implies an important role of PD-1/PD-L1 in peripheral immune tolerance in cGVHD after alloHSCT and warrants further investigation. (C) 2017 S. Karger GmbH, Freiburg
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST-DISEASE; REFRACTORY HODGKINS LYMPHOMA; STEM-CELL TRANSPLANTATION; T-CELLS; NIVOLUMAB; PATHWAY; EXPRESSION; LETHALITY; BLOCKADE; PATIENT; Hodgkin's lymphoma; Immunotherapy; Stem cell transplantation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:01 |
| Last Modified: | 19 Feb 2019 14:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/646 |
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