Hafkesbrink, Moritz and Schemmerer, Mathias and Wenzel, Jürgen J. and Isenmann, S. (2025) Acute hepatitis E virus infection presenting as meningo-encephalitis. INFECTION, 53 (1). pp. 475-479. ISSN 0300-8126, 1439-0973
Full text not available from this repository. (Request a copy)Abstract
BackgroundAcute hepatitis E infection (HEV), with its high incidence in Europe, should be considered as a differential diagnosis of acute viral hepatitis and can in some cases manifest with pronounced neurological symptoms.Clinical CaseWe report on a 33-year-old female patient with severe arthralgia, myalgia, headache and psychomotor deterioration. Laboratory analyses showed elevated transaminases without signs of cholestasis. Acute hepatitis E virus infection was detected in serum. She reported fatigue and dysesthesias not responsive to analgesics. Cerebrospinal fluid (CSF) analysis revealed an inflammatory syndrome. HEV RNA was detected in the CSF. The infection remained mild, but dysesthesias persisted. Eight weeks after the first admission, the symptoms worsened again. Complete and sustained remission was achieved following intravenous corticosteroid treatment.ConclusionIn patients with acute neurological symptoms and liver enzyme elevation, HEV infection should be considered. Neurologic symptoms such as fatigue, arthralgia, myalgia and dysesthesia along with psychomotor retardation should prompt CSF analysis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EPIDEMIOLOGY; GERMANY; CSF; Pleocytosis; Acute hepatitis E infection; HEV; Meningo-encephalitis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Mar 2026 06:49 |
| Last Modified: | 24 Mar 2026 06:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64641 |
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